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TYROSINE HYDROXYLASE. THE INITIAL STEP IN NOREPINEPHRINE BIOSYNTHESIS.
TLDR
It has now been possible to demonstrate that brain, adrenal medulla, and sympathetically innervated tissues contain a specific hydroxylase that catalyzes the conversion of L-tyrosine to dopa. Expand
ELUCIDATION OF THE RATE-LIMITING STEP IN NOREPINEPHRINE BIOSYNTHESIS IN THE PERFUSED GUINEA-PIG HEART.
TLDR
Factors indicate that conversion of tyrosine to dopa is the rate-limiting step in the formation of norepinephrine in the sympathetic nervous system and ascorbic acid has been shown to be a requirement for purified dopamine-β-oxidase activity. Expand
Pancreatic endocrine function in cystic fibrosis.
TLDR
Either that exocrine disease causes endocrine dysfunction in CF or that a common pathogenic process simultaneously and independently impairs exocrine and endocrine function is suggested. Expand
Conversion of L-tyrosine to 3,4-dihydroxyphenylalanine by cell-free preparations of brain and sympathetically innervated tissues.
TLDR
It has now been possible tyrosine → DOPA → DPAmine → noradrenaline to obtain mitochondrial fractions from brain and adrenal medulla which can hydroxylate L-tyrosine to DOPA. Expand
Phenylalanine as substrate and inhibitor of tyrosine hydroxylase.
TLDR
Experimental data indicate that one enzyme catalyzes both reactions and that hydroxylation of phenylalanine to 3,4-dihydroxyphenylAlanine occurs in two independent steps with free tyrosine as an intermediate. Expand
Norepinephrine Synthesis from Tyrosine-C14 in Isolated Perfused Guinea Pig Heart
TLDR
The isolated, perfused guinea pig heart contains all the catalysts required to form norepinephrine from the dietary precursor, tyrosine, and it is not necessary to postulate that the hormone is extracted from the blood. Expand
A new class of tyrosine hydroxylase inhibitors and a simple assay of inhibition in vivo.
TLDR
A rapid and simple method is described for measuring tyrosine hydroxylase inhibition in the press juice from guinea pig heart after the administration in vivo of various compounds, which are consistent with the inhibition of the enzyme in vivo as estimated by other procedures. Expand
NOREPINEPHRINE SYNTHESIS AND RELEASE IN VIVO MEDIATED BY 3,4-DIHYDROXYPHENETHYLAMINE.
TLDR
These findings explain how dopamine can cause norepinephrine release, with its consequent pharmacologic response, without effecting a net change in tissue norpinephrine levels. Expand
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