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Morphological and molecular markers are correlated with maturation-competence of human oocytes.
STUDY QUESTION Does the position of the germinal vesicle (GV) in human oocytes correlate with molecular and morphological parameters as well as with maturation-competence? SUMMARY ANSWER The… Expand
Interleukin-1 deficiency prolongs ovarian lifespan in mice
- Shiri Uri-Belapolsky, A. Shaish, +11 authors Y. Kamari
- Medicine, Biology
- Proceedings of the National Academy of Sciences
- 11 August 2014
Significance Females are subjected to a biological clock that dictates the end of the reproductive lifespan, on average, at 50 y of age, whereas fecundity sharply decreases after 30 y of age. Over… Expand
Fyn kinase is involved in cleavage furrow ingression during meiosis and mitosis.
Fertilization of mammalian oocytes triggers their exit from the second meiotic division metaphase arrest. The extrusion of the second polar body (PBII) that marks the completion of meiosis is… Expand
The involvement of Fyn kinase in resumption of the first meiotic division in mouse oocytes
The process of resumption of the first meiotic division (RMI) in mammalian oocytes includes germinal vesicle breakdown (GVBD), spindle formation during first metaphase (MI), segregation of homologous… Expand
Doxorubicin-Induced Vascular Toxicity – Targeting Potential Pathways May Reduce Procoagulant Activity
Introduction Previous study in mice using real-time intravital imaging revealed an acute deleterious effect of doxorubicin (DXR) on the gonadal vasculature, as a prototype of an end-organ, manifested… Expand
Dexrazoxane exacerbates doxorubicin-induced testicular toxicity.
- M. Levi, Moran Tzabari, N. Savion, S. Stemmer, R. Shalgi, I. Ben-Aharon
- Biology, Medicine
- 1 October 2015
Infertility induced by anti-cancer treatments pose a major concern for cancer survivors. Doxorubicin (DXR) has been previously shown to exert toxic effects on the testicular germinal epithelium.… Expand
Anti-Müllerian Hormone Is a Marker for Chemotherapy-Induced Testicular Toxicity.
Due to increased numbers of young cancer patients and improved survival, the impact of anticancer treatments on fertility has become a major health concern. Despite mounting research on ovarian… Expand
Localized measurements of physical parameters within human sperm cells obtained with wide-field interferometry.
- Michal Balberg, M. Levi, K. Kalinowski, I. Barnea, Simcha K. Mirsky, N. Shaked
- Chemistry, Medicine
- Journal of biophotonics
- 1 October 2017
We developed a new method to identify the separate cellular compartments in the optical path delay (OPD) maps of un-labeled spermatozoa. This was conducted by comparing OPD maps of fixed, un-labeled… Expand
Interleukin 1-alpha deficiency increases the expression of Follicle-stimulating hormone receptors in granulosa cells.
- Shiri Uri-Belapolsky, Irit Miller, +5 authors R. Shalgi
- Medicine, Biology
- Molecular reproduction and development
- 1 June 2017
Follicle-stimulating hormone receptor (FSHR) is a pivotal regulator of ovarian response to hormonal stimulation. Inflammatory conditions have been linked to lower FSHR expression in granulosa cells… Expand
MicroRNA miR-125a-3p modulates molecular pathway of motility and migration in prostate cancer cells
Fyn kinase is implicated in prostate cancer. We illustrate the role of miR-125a-3p in cellular pathways accounted for motility and migration of prostate cancer cells, probably through its regulation… Expand