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Soluble endoglin contributes to the pathogenesis of preeclampsia
A novel placenta-derived soluble TGF-β coreceptor, endoglin (sEng), which is elevated in the sera of preeclamptic individuals, correlates with disease severity and falls after delivery, suggest that sEng may act in concert with sFlt1 to induce severe preeclampsia.
Endoglin is a component of the transforming growth factor-beta receptor system in human endothelial cells.
Endoglin, a TGF-β binding protein of endothelial cells, is the gene for hereditary haemorrhagic telangiectasia type 1
Endoglin is identified as the HHT gene mapping to 9q3 and HHT is established as the first human disease defined by a mutation in a member of the TGF-β receptor complex.
Endoglin Is an Accessory Protein That Interacts with the Signaling Receptor Complex of Multiple Members of the Transforming Growth Factor-β Superfamily*
- Nadia Barbara, J. Wrana, M. Letarte
- Biology, ChemistryThe Journal of Biological Chemistry
- 8 January 1999
The data suggest that endoglin is an accessory protein of multiple kinase receptor complexes of the TGF-β superfamily.
A murine model of hereditary hemorrhagic telangiectasia.
- A. Bourdeau, D. Dumont, M. Letarte
- Biology, MedicineThe Journal of clinical investigation
- 15 November 1999
It is suggested that endoglin is critical for both angiogenesis and heart valve formation and epigenetic factors and modifier genes, some of which are present in 129/Ola, contribute to disease heterogeneity.
Hereditary haemorrhagic telangiectasia: current views on genetics and mechanisms of disease
Current knowledge on the genetics of HHT is summarised, including the pathways that link the genes responsible for HHT and the potential mechanisms underlying the pathogenesis of the disease.
Hereditary haemorrhagic telangiectasia and pulmonary arteriovenous malformations: issues in clinical management and review of pathogenic mechanisms
Hereditary haemorrhagic telangiectasia (HHT, Rendu-Osler-Weber syndrome) exemplifies an important group of diseases which have catalysed advances in the understanding of fundamental…
Endoglin modulates cellular responses to TGF-beta 1
It is observed that TGF-beta itself can stimulate the expression of endoglin in cultured human monocytes and in the U-937 monocytic line, and this should increase the understanding of the complex pathways which mediate the effects of this factor.
Identification of a human endothelial cell antigen with monoclonal antibody 44G4 produced against a pre-B leukemic cell line.
Staining of a variety of human tissue sections by the indirect immunoperoxidase method indicated that mAb 44G4, produced against a human pre-B leukemic cell line, was strongly reactive with vascular endothelium.