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Healthy Effects of Plant Polyphenols: Molecular Mechanisms
TLDR
The findings reported in the last decade are starting to help to decipher the complex relations between plant polyphenols and cell homeostatic systems including metabolic and redox equilibrium, proteostasis, and the inflammatory response, establishing an increasingly solid molecular basis for the healthy effects of these molecules. Expand
Oleuropein aglycone stabilizes the monomeric α-synuclein and favours the growth of non-toxic aggregates
TLDR
It is shown that oleuropein aglycone (OleA), the main olive oil polyphenol, exhibits anti-amyloidogenic power in vitro by interacting with, and stabilizing, α-synuclein monomers thus hampering the growth of on-pathway oligomers and favouring thegrowth of stable and harmless aggregates with no tendency to evolve into other cytotoxic amyloids. Expand
Oleuropein aglycone: A polyphenol with different targets against amyloid toxicity.
TLDR
This study reveals that OleA remodels not only D76N b2m aggregates but also the cell membrane interfering with the misfolded proteins-cell membrane association, in most cases an early event triggering amyloid-mediated cytotoxicity. Expand
Healthspan Maintenance and Prevention of Parkinson’s-like Phenotypes with Hydroxytyrosol and Oleuropein Aglycone in C. elegans
TLDR
Hormesis, antioxidative capacities and an activity-boost of the proteasome & phase II detoxifying enzymes are discussed as potential underlying causes for these beneficial effects and further biological and medical trials are indicated to assess the full potential of HT and OLE. Expand
The polyphenol Oleuropein aglycone hinders the growth of toxic transthyretin amyloid assemblies.
TLDR
The data offer the possibility to validate and optimize the use of OleA or its molecular scaffold to rationally design promising drugs against TTR-related pathologies that could enter a clinical experimental phase and the molecular basis of such interference and the resulting reduction of TTR amyloid aggregate cytotoxicity are described. Expand
Oleuropein aglycone and hydroxytyrosol interfere differently with toxic Aβ1-42 aggregation.
TLDR
The data demonstrate that, by stabilizing oligomers and fibrils, both polyphenols reduce their seeding activity and aggregate/membrane interaction on human neuroblastoma SH-SY5Y cells, and offer the possibility to validate and to optimize their use for possible AD prevention and therapy. Expand
Molecular insights into cell toxicity of a novel familial amyloidogenic variant of β2‐microglobulin
TLDR
It is observed that the aggregates bind to the cell membrane inducing an alteration of its elasticity (with possible functional unbalance and cytotoxicity) in GM1‐enriched domains only, thus establishing a link between aggregate‐membrane contact and cell damage. Expand
Insight into the molecular mechanism underlying the inhibition of α-synuclein aggregation by hydroxytyrosol.
TLDR
Results show that HT dose-dependently inhibits Syn aggregation and that covalent and non-covalent binding mediate HT-Syn interaction, and cellular assays showed that HT reduces the toxicity of Syn aggregates. Expand
Successful Brain Delivery of Andrographolide Loaded in Human Albumin Nanoparticles to TgCRND8 Mice, an Alzheimer’s Disease Mouse Model
TLDR
AG NPs have extraordinary versatility, nontoxicity, nonimmunogenicity, strong biocompatibility, high biodegradability, and astonishing loading capacity of drug. Expand
A FTIR microspectroscopy study of the structural and biochemical perturbations induced by natively folded and aggregated transthyretin in HL-1 cardiomyocytes
TLDR
Fourier transform infrared microspectroscopy was exploited to investigate in situ the spectral changes occurring in cultured intact HL-1 cardiomyocytes exposed to wild type (WT) or mutant (L55P) transthyretin (TTR) in native, or amyloid conformation and found that the major effects were observed when natively folded WT or L55P TTR was administered to the cells. Expand
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