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Influence of the antibiotics erythromycin and azithromycin on the pharmacokinetics and pharmacodynamics of midazolam.
- T. Zimmermann, R. Yeates, H. Laufen, F. Scharpf, M. Leitold, A. Wildfeuer
- 1 February 1996
Pharmacodynamic tests consistently showed significant differences after erythromycin pretreatment compared to control, but not after azithromycin, which causes clinically significant changes in the pharmacokinetics and pharmacodynamics of midazolam. Expand
The reaction between organic nitrates and sulfhydryl compounds. A possible model system for the activation of organic nitrates.
It is suggested that, in vivo, a thionitrate could function as an important intermediate in the activation of guanylate cyclase. Expand
Enantioselective disposition of oral amlodipine in healthy volunteers.
It is proposed that the observed enantioselectivity of oral amlodipine is due to differences in the systemic blood clearance of the enantiomers. Expand
The influence of food intake on gastrointestinal pH and gastric emptying time. Experience with two radiotelemetering methods: (Heidelberg pH capsule system and Flexilog 1010).
Antagonism of glycerol trinitrate activity by an inhibitor of glutathione S-transferase.
It is concluded that sulphobromophthalein acts as a specific antagonist of the spasmolytic activity of glycerol trinitrate, probably as a result of its inhibition of glutathione S-transferase. Expand
Enantioselective gas chromatographic assay with electron-capture detection for amlodipine in biological samples.
- F. Scharpf, K. Riedel, H. Laufen, M. Leitold
- Chemistry, Medicine
- Journal of chromatography. B, Biomedical…
- 13 May 1994
A sensitive enantioselective gas chromatographic assay has been developed for amlodipine, a calcium channel blocking therapeutic agent, and has been used for the measurement of amlidipine enantiomers in human, rat and dog plasma, and in various organs of the rat. Expand
Comparison of the pharmacokinetics of three-day and five-day regimens of azithromycin in plasma and urine.
- A. Wildfeuer, H. Laufen, M. Leitold, T. Zimmermann
- The Journal of antimicrobial chemotherapy
The observed pharmacokinetics of azithromycin with both regimens conformed with the known pharmacokinetic behaviour of the drug. Expand
Oral absorption and disposition of isosorbide dinitrate and isosorbide mononitrates in man.
The plasma concentrations of ISDN and its two pharmacologically active metabolites isosorbide 2-mononitrate (IS-2-MN) and IS-5-MN were determined after oral administration of 20 mg IS DN and 20 mg of each of the mononitrates. Expand
The effect of activated charcoal on the bioavailability of piroxicam in man.
The effect of single and multiple oral doses of activated charcoal (a.c.) on the plasma concentrations of piroxicam was investigated in a cross-over study in 6 healthy volunteers and it was inferred that piroXicam is subject to enteral circulation. Expand
Anti-ulcer and secretion-inhibitory properties of the tricyclic derivative doxepin in rats and dogs.
To inhibit the secretion of saliva and to delay intestinal transport, a dose of doxepin 3-10 times greater than that required for anti-ulcerative and secretion-inhibitory effects was necessary. Expand