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Evaluation of three parasite lactate dehydrogenase-based rapid diagnostic tests for the diagnosis of falciparum and vivax malaria
None of the pLDH-based RDTs evaluated was able to detect non-falciparum malaria with high sensitivity, particularly at low parasitaemias, and OptiMAL-IT® performed best overall and would perform best in an area of high malaria prevalence among screened fever cases. Expand
Lupeol long-chain fatty acid esters with antimalarial activity from Holarrhena floribunda.
- J. Fotie, D. S. Bohle, M. Leimanis, E. Georges, G. Rukunga, A. E. Nkengfack
- Biology, Medicine
- Journal of natural products
An ethnopharmacological investigation was conducted among the Baka pygmies of Dja biosphere reserve (Cameroon) to collect information on the antimalarial plants used in their daily life, and extracts of H. floribunda showed remarkable inhibitory activity against drug-resistant strains of Plasmodium falciparum. Expand
The leucotriene C4 binding sites in multidrug resistance protein 1 (ABCC1) include the first membrane multiple spanning domain.
A novel photoreactive azido analogue of LTC(4) (AALTC( 4) is synthesized and characterized and shown to provide the first direct evidence for LTC (4) binding within MSD0. Expand
Chloroquine resistant vivax malaria in a pregnant woman on the western border of Thailand
This is the first clinically and laboratory confirmed case of two high-grade CQ resistant vivax parasite strains from Thailand. Expand
Evolving Management of Zenker’s Diverticulum in the Endoscopic Era: A North American Experience
FlexCM represents an excellent approach for large ZD, while OpenCM should be reserved for small ZD for which an overtube cannot be positioned, and Open and endoscopic approaches offer comparable outcomes and dysphagia resolution. Expand
Job Satisfaction Among Volunteers With Personal Cancer Experience
Findings from the quantitative and qualitative inquiries indicated that the level of job satisfaction was high and stress was not reported as a major concern, plus the need to explore supports to sustain oncology volunteers in this most challenging environment is explored. Expand
Modulation of GSH levels in ABCC1 expressing tumor cells triggers apoptosis through oxidative stress.
- Rémi-Martin Laberge, J. Karwatsky, M. C. Lincoln, M. Leimanis, E. Georges
- Biology, Medicine
- Biochemical pharmacology
- 1 June 2007
It is demonstrated that ABCC1 potentiates oxidative stress in tumor cells through reductions in cellular GSH levels, as demonstrated in H69AR-drug selected and HeLa/ABCC1-transfectant cells. Expand
Plasmodium vivax Susceptibility to Ferroquine
- M. Leimanis, A. Jaidee, +7 authors F. Nosten
- Medicine, Biology
- Antimicrobial Agents and Chemotherapy
- 1 May 2010
The novel organometallic chloroquine analog ferroquine (SSR 97193) is effective against chloroquin-resistant Plasmodiumfalciparum and may be a suitable replacement for chloroquines in the treatment of drug-resistant P. vivax malaria. Expand
Effective and cheap removal of leukocytes and platelets from Plasmodium vivax infected blood
CF11 filtration is the most cost and time efficient method for the production of leukocyte- and platelet-free P. vivax-infected erythrocytes from field isolates. Expand
Considerations on the use of nucleic acid-based amplification for malaria parasite detection
Variations in the sensitivity of a given PCR assay primarily diminish the ability to detect low-level and mixed infections and are sufficient to obviate the main rationale to use PCR assays rather than microscopy or rapid diagnostic tests. Expand