Microbial fermentation-derived inhibitors of efflux-pump-mediated drug resistance.
- M. Lee, J. Galazzo, G. Miller
- Biology, ChemistryIl Farmaco
- 1 March 2001
New antitumor antibiotic, LL-C10037 alpha. Fermentation, isolation and structure determination.
- M. Lee, A. Fantini, G. Morton, J. C. James, D. Borders, R. Testa
- Chemistry, BiologyJournal of antibiotics (Tokyo. )
- 1 October 1984
A new antitumor antibiotic, LL-C10037 alpha was isolated from the fermentation filtrate of a Streptomyces by adsorption, partition and reverse phase column chromatography. Its chemical structure was…
Calicheamicins, a novel family of antitumor antibiotics. 3. Isolation, purification and characterization of calicheamicins beta 1Br, gamma 1Br, alpha 2I, alpha 3I, beta 1I, gamma 1I and delta 1I.
- M. Lee, J. Manning, D. Williams, N. Kuck, R. Testa, D. Borders
- Biology, ChemistryJournal of antibiotics (Tokyo. )
- 25 July 1989
Novel antitumor antibiotics, calicheamicins beta 1Br, gamma 1Br, alpha 2I, alpha 3I, beta 1I, gamma 1I and delta 1I were recovered from the fermentation broth of Micromonospora echinospora ssp.…
Stereochemical elucidation and total synthesis of dihydropacidamycin D, a semisynthetic pacidamycin.
- C. Boojamra, R. Lemoine, V. Lee
- Chemistry, BiologyJournal of the American Chemical Society
- 11 January 2001
The stereochemical identities of the tryptophan and two alanine residues contained in pacidamycin D have been shown to be of the natural (S,3S) configuration, and the unique 3-methylamino-2-aminobutyric acid contained in this series of antibiotics has been shownto be ofThe stereochemistry obtained by hydrogenation of the C(4')-C(5') exocyclic olefin has been shows to be (
New pacidamycins produced by Streptomyces coeruleorubidus, NRRL 18370.
- R. Fronko, J. C. Lee, J. Galazzo, S. Chamberland, F. Malouin, M. Lee
- ChemistryJournal of antibiotics (Tokyo. )
- 25 December 2000
Glycothiohexide alpha, a novel antibiotic produced by "Sebekia" sp., LL-14E605. II. Isolation and physical-chemical characterization.
- P. Northcote, D. Williams, J. Manning, D. Borders, W. Maiese, M. Lee
- Biology, ChemistryJournal of antibiotics (Tokyo. )
- 1 August 1994
Glycothiohexide alpha was recovered from the fermentation broth of a "Sebekia" sp. by mixed solvent extraction, selective precipitation and adsorption chromatography on Diaion HP-20. The amount of…
Glycothiohexide alpha, a novel antibiotic produced by "Sebekia" sp., LL-14E605. III. Structural elucidation.
- P. Northcote, M. Siegel, D. Borders, M. Lee
- ChemistryJournal of antibiotics (Tokyo. )
- 1994
The chemical structure of a novel thiopeptide antibiotic, glycothiohexide alpha (1), isolated from the fermentation broth of a "Sebekia" species was determined based on extensive 2D NMR studies, as…
New antitumor antibiotic, LL-D05139 beta. Fermentation, isolation, structure determination and biological activities.
- M. Lee, A. Fantini, N. Kuck, M. Greenstein, R. Testa, D. Borders
- Chemistry, BiologyJournal of antibiotics (Tokyo. )
- 25 December 1987
LL-D05139 beta demonstrated greater antibacterial and biochemical induction assay activities than azaserine, and the two drugs showed similar antitumor activities.
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