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Requirement of the orphan nuclear receptor SF-1 in terminal differentiation of ventromedial hypothalamic neurons
The ventromedial hypothalamic nucleus (VMN) is known to mediate autonomic responses in feeding and reproductive behaviors. To date, the most definitive molecular marker for the VMN is the orphanExpand
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DEAD-box helicase DP103 defines metastatic potential of human breast cancers.
Despite advancement in breast cancer treatment, 30% of patients with early breast cancers experience relapse with distant metastasis. It is a challenge to identify patients at risk for relapse;Expand
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Betaine analogues alter homocysteine metabolism in rats.
Glycine betaine supplementation lowers homocysteine levels in homocystinuria and in chronic renal failure patients through methylation catalysed by betaine-homocysteine methyltransferase (BHMT). TheExpand
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Water fluoridation and dental caries in 5- and 12-year-old children from Canterbury and Wellington.
OBJECTIVES Claims have been made that the effectiveness of water fluoridation has reduced due to the widespread availability of other sources of fluoride. This study examines the differences in theExpand
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A nuclear-magnetic-resonance-based assay for betaine-homocysteine methyltransferase activity.
Betaine-homocysteine methyltransferase (BHMT) activity can be measured directly and kinetically by (1)H-nuclear magnetic resonance spectroscopy. The disappearance of substrates and the formation ofExpand
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Validation of (1)H NMR spectroscopy as an analytical tool for methylamine metabolites in urine.
BACKGROUND Methylamines have many metabolic roles and there is an increasing demand for their measurement. Glycine betaine is an important osmolyte, and a reservoir for methyl groups. Proline betaineExpand
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Wanted DEAD/H or Alive: Helicases Winding Up in Cancers
Cancer is one of the most studied areas of human biology over the past century. Despite having attracted much attention, hype, and investments, the search to find a cure for cancer remains an uphillExpand
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Dimethylglycine supplementation does not affect plasma homocysteine concentrations in pre-dialysis chronic renal failure patients.
OBJECTIVE To determine whether daily dimethylglycine supplementation affects plasma homocysteine concentrations. DESIGN AND METHODS A randomized, blinded, crossover design was used. SevenExpand
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Pushing the limits of immune-related response: a case of “extreme pseudoprogression”
The advent of immune checkpoint targeted immunotherapy has seen a spectrum of immune-related phenomena in both tumor responses and toxicities. We describe a case of pseudoprogression that pushes theExpand
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