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Epithelial-mesenchymal transition (EMT) in kidney fibrosis: fact or fantasy?
Epithelial-mesenchymal transition (EMT) has become widely accepted as a mechanism by which injured renal tubular cells transform into mesenchymal cells that contribute to the development of fibrosisExpand
Inhibition of mTOR with sirolimus slows disease progression in Han:SPRD rats with autosomal dominant polycystic kidney disease (ADPKD).
BACKGROUND Autosomal dominant polycystic kidney disease (ADPKD) is characterized by dysregulated tubular epithelial cell growth, resulting in the formation of multiple renal cysts and progressiveExpand
Proliferation capacity of the renal proximal tubule involves the bulk of differentiated epithelial cells.
We investigated the proliferative capacity of renal proximal tubular cells in healthy rats. Previously, we observed that tubular cells originate from differentiated cells. We now found 1) byExpand
Podocyte bridges between the tuft and Bowman's capsule: an early event in experimental crescentic glomerulonephritis.
Although experimental crescentic glomerulonephritis starts with an endocapillary inflammation, the crescents themselves seem to originate from the proliferation of parietal epithelial cells (PEC). InExpand
Distribution and regulation of renal ecto-5'-nucleotidase: implications for physiological functions of adenosine.
Adenosine exerts various effects via membrane receptors in the kidney. It reduces the glomerular filtration rate by altering the resistance of the glomerular arterioles, and it inhibits the releaseExpand
Co-localization of erythropoietin mRNA and ecto-5'-nucleotidase immunoreactivity in peritubular cells of rat renal cortex indicates that fibroblasts produce erythropoietin.
In adults, the kidneys are the major site of production of the glycoprotein hormone erythropoietin (EPO), but the type of renal cell producing EPO has not yet been identified. In the present study weExpand
Podocytes populate cellular crescents in a murine model of inflammatory glomerulonephritis.
Cellular crescents are a defining histologic finding in many forms of inflammatory glomerulonephritis. Despite numerous studies, the origin of glomerular crescents remains unresolved. A genetic cellExpand
Differential effects of TNF and LTα in the host defense against M. bovis BCG
Signaling via TNF receptor type 1 (TNFR1) was shown to be crucial in host defense against the intracellular pathogens L. monocytogenes, M. tuberculosis and M. bovis. Toinvestigate the function of TNFExpand
Renal tubular epithelial expression of the costimulatory molecule B7RP-1 (inducible costimulator ligand).
MHC class II-expressing renal tubular epithelial cells (TEC) are able to present foreign peptide antigens to T cells. The costimulatory signals that are required for effective T cell activation uponExpand