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A syndrome of peripheral lipodystrophy, hyperlipidaemia and insulin resistance in patients receiving HIV protease inhibitors
TLDR
A syndrome of peripheral lipodystrophy, hyperlipidaemia and insulin resistance is a common complication of HIV protease inhibitors and diabetes mellitus is relatively uncommon. Expand
Class of antiretroviral drugs and the risk of myocardial infarction.
TLDR
Investigation of the association of cumulative exposure to protease inhibitors and nonnucleoside reverse-transcriptase inhibitors with the risk of myocardial infarction found no evidence of such an association for nonn nucleosidereverse-transcriptionase inhibitors; however, the number of person-years of observation for exposure to this class of drug was less than that for Exposure to prote enzyme inhibitors. Expand
Liver-related deaths in persons infected with the human immunodeficiency virus: the D:A:D study.
TLDR
A strong association between immunodeficiency and risk of liver-related death was found and long-term follow-up is required to investigate whether clinically significant treatment-associated liver- related mortality will develop. Expand
Combination antiretroviral therapy and the risk of myocardial infarction.
TLDR
Combination antiretroviral therapy was independently associated with a 26 percent relative increase in the rate of myocardial infarction per year of exposure during the first four to six years of use, however, the absolute risk of my Cardiac Infarction was low and must be balanced against the marked benefits from antireTroviral treatment. Expand
Plasma levels of soluble CD14 independently predict mortality in HIV infection.
TLDR
Therapeutic attenuation of innate immune activation may improve survival in patients with HIV infection and sCD14, a marker of monocyte response to LPS, is an independent predictor of mortality in HIV infection. Expand
Use of nucleoside reverse transcriptase inhibitors and risk of myocardial infarction in HIV-infected patients enrolled in the D:A:D study: a multi-cohort collaboration
TLDR
There exists an increased risk of myocardial infarction in patients exposed to abacavir and didanosine within the preceding 6 months and the excess risk does not seem to be explained by underlying established cardiovascular risk factors and was not present beyond 6 months after drug cessation. Expand
Risk of myocardial infarction in patients with HIV infection exposed to specific individual antiretroviral drugs from the 3 major drug classes: the data collection on adverse events of anti-HIV drugs
TLDR
Indinavir, lopinavir-ritonavir, didanosine, and abacavir were associated with a significantly increased risk of MI and must be interpreted with caution (given the potential for confounding) in the context of the benefits that these drugs provide. Expand
Cardiovascular disease risk factors in HIV patients – association with antiretroviral therapy. Results from the DAD study
TLDR
Of specific concern is the fact that use of the NNRTI and PI drug classes (alone and especially in combination), particularly among older subjects with normalized CD4 cell counts and suppressed HIV replication, was associated with a lipid profile known to increase the risk of coronary heart disease. Expand
Mortality among clients of a state-wide opioid pharmacotherapy program over 20 years: risk factors and lives saved.
TLDR
Mortality among treatment-seeking opioid-dependent persons is dynamic across time, patient and treatment variables, and despite periods of elevated risk, this large-scale provision of pharmacotherapy is estimated to have resulted in significant reductions in mortality. Expand
Cancer incidence before and after kidney transplantation.
TLDR
Comparing the incidence of cancer in patients receiving immune suppression after kidney transplantation with incidence in the same population in 2 periods before receipt of immune suppression suggests a broader than previously appreciated role of the interaction between the immune system and common viral infections in the etiology of cancer. Expand
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