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Pharmacology of Cortical Epileptic Afterdischarges in Rats
The findings suggest that cortically induced ADS are not a good model of secondarily generalized seizures, and the response to VPA and PB suggests that cortical ADS may represent a model of myoclonic seizures.
Ketamine blocks cortical epileptic afterdischarges but not paired-pulse and frequency potentiation
Anti-metrazol action of R 57720 during postnatal development in rats.
R 57720 exhibited a marked dose-dependent anticonvulsant effect against major, generalized tonic-clonic seizures in all the age groups studied, and similar action on minimal metrazol seizures (mMS) was present in rats aged 18 days and more.