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Cembranolides from the stem bark of the southern African medicinal plant, Croton gratissimus (Euphorbiaceae).
The stem bark of Croton gratissimus (Euphorbiaceae) yielded four cembranolides, including the first reported example of a 2,12-cyclocembranolide, whose structure was confirmed by means of single crystal X-ray analysis. Expand
New ent-Clerodane and Abietane Diterpenoids from the Roots of Kenyan Croton megalocarpoides Friis & M. G. Gilbert.
The roots of the endangered medicinal plant Croton megalocarpoides collected in Kenya were investigated and twenty-two compounds isolated, which contained twelve new ent-clerodane and a new abietane diterpenoids and were evaluated against a series of microorganisms and against Plasmodium falciparum, however no activity was observed. Expand
Cembranolides from the leaves of Croton gratissimus.
Ten new cembranolides have been isolated from the leaves of Croton gratissimus and the acetyl derivatives of 8 and 4a were evaluated against a chloroquine-sensitive strain of Plasmodium falciparum (D10). Expand
Diterpenoids from the roots of Croton dichogamus Pax.
Ten-epi-Maninsigin D reduced Caco-2 cell viability at 10, 30 and 100 μM, with values of decreased viability of 28, 48% and 43% respectively, and none of the other tested compounds showed significant activity. Expand
Alienusolin, a new 4α-deoxyphorbol ester derivative, and crotonimide C, a new glutarimide alkaloid from the Kenyan Croton alienus.
Two novel compounds, alienusolin, a 4α-deoxyphorbol ester, and crotonimide C, a glutarimide alkaloid derivative, and ten known compounds were isolated from the Kenyan Croton alienus using NMR, GCMS, and HRESIMS studies. Expand
A Review of the Ethnomedicinal Uses, Biological Activities, and Triterpenoids of Euphorbia Species
It is envisaged that the report on Euphorbia triterpenoids with interesting anticancer activities will form a database of potential leads or scaffolds that could be advanced into the clinical trials with regard to drug discovery. Expand
Flagellum Removal by a Nectar Metabolite Inhibits Infectivity of a Bumblebee Parasite
It is concluded that plant secondary metabolites can disrupt parasite flagellum attachment, revealing a mechanism behind their prophylactic effects. Expand
COX-2 inhibitory activity of homoisoflavanones and xanthones from the bulbs of the Southern African Ledebouria socialis and Ledebouria ovatifolia (Hyacinthaceae: Hyacinthoideae).
The bulbs of Ledebouria socialis and ovatifolia yielded the benzocyclobutene homoisoflavonoid and xanthones isolated were evaluated against cyclooxygenase-1 and -2 isoenzymes. Expand
Ent-kauren-19-oic acid derivatives from the stem bark of Croton pseudopulchellus Pax
Two new ent -kauren-19-oic acid derivatives, including the major constituent, showed weak activity against the Plasmodium falciparum (CQS) D10 strain and were tested for their effects on Semliki Forest virus replication and for cytotoxicity against human liver tumour cells (Huh-7 strain). Expand
Application of Residual Dipolar Couplings and Selective Quantitative NOE to Establish the Structures of Tetranortriterpenoids from Xylocarpus rumphii.
Nine triterpenoid derivatives were isolated from the heartwood of Xylocarpus rumphii and were identified as xylorumphiins E (1), C (2), L (3), and M-R (4-9). Compounds 4-9 have a hemiacetal group inExpand