• Publications
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Intermittent fasting dissociates beneficial effects of dietary restriction on glucose metabolism and neuronal resistance to injury from calorie intake
Dietary restriction has been shown to have several health benefits including increased insulin sensitivity, stress resistance, reduced morbidity, and increased life span. The mechanism remainsExpand
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Interoperability of biodiversity databases: biodiversity information on every desktop.
Global Biodiversity Information Facility (GBIF) is a framework for facilitating the digitization of biodiversity data and for making interoperable an as-yet-unknown number of biodiversity databases that are distributed around the globe. Expand
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Caloric restriction increases neurotrophic factor levels and attenuates neurochemical and behavioral deficits in a primate model of Parkinson's disease
We report that a low-calorie diet can lessen the severity of neurochemical deficits and motor dysfunction in a primate model of Parkinson's disease. Adult male rhesus monkeys were maintained for 6Expand
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Longevity and the genetic determination of collagen glycoxidation kinetics in mammalian senescence.
  • D. Sell, M. Lane, +8 authors V. Monnier
  • Medicine, Biology
  • Proceedings of the National Academy of Sciences…
  • 9 January 1996
A fundamental question in the basic biology of aging is whether there is a universal aging process. If indeed such a process exists, one would expect that it develops at a higher rate in short-Expand
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Caloric Restriction in Primates and Relevance to Humans
Abstract: Dietary caloric restriction (CR) is the only intervention conclusively and reproducibly shown to slow aging and maintain health and vitality in mammals. Although this paradigm has beenExpand
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Diet restriction in rhesus monkeys lowers fasting and glucose-stimulated glucoregulatory end points.
Male rhesus monkeys (Macaca mulatta) of different age groups representing the species life span were fed ad libitum or a 30% reduced calorie diet over a 7-yr period. During the first 2-3 yr of thisExpand
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Chronic ingestion of 2-deoxy-D-glucose induces cardiac vacuolization and increases mortality in rats.
Calorie restriction (CR), the purposeful reduction of energy intake with maintenance of adequate micronutrient intake, is well known to extend the lifespan of laboratory animals. Compounds likeExpand
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Calorie restriction lowers body temperature in rhesus monkeys, consistent with a postulated anti-aging mechanism in rodents.
  • M. Lane, D. Baer, +5 authors G. Roth
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 30 April 1996
Many studies of caloric restriction (CR) in rodents and lower animals indicate that this nutritional manipulation retards aging processes, as evidenced by increased longevity, reduced pathology, andExpand
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Flower petal microtexture is a tactile cue for bees.
  • P. G. Kevan, M. Lane
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 1 July 1985
Honeybees are shown to be able to detect, learn, and discriminate between microsculptured epidermes of flower petals. The sensilla trichodea at the tips of the bees' antennae are in the same sizeExpand
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Calorie restriction mimetics: an emerging research field
When considering all possible aging interventions evaluated to date, it is clear that calorie restriction (CR) remains the most robust. Studies in numerous species have demonstrated that reduction ofExpand
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