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Clonal hematopoiesis and blood-cancer risk inferred from blood DNA sequence.
Clonal hematopoiesis with somatic mutations is readily detected by means of DNA sequencing, is increasingly common as people age, and is associated with increased risks of hematologic cancer and death.
Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs
Empirical evidence of shared genetic etiology for psychiatric disorders can inform nosology and encourages the investigation of common pathophysiologies for related disorders.
Genome-wide association study identifies 30 Loci Associated with Bipolar Disorder
The largest genome-wide association study to date, including 20,352 cases and 31,358 controls of European descent, with follow-up analysis of 881 sentinel variants at loci with P<1×10-4, achieves genome- wide significance including 18 novel loci, which provide potential new biological mechanisms for bipolar disorder.
A mega-analysis of genome-wide association studies for major depressive disorder
Although this is the largest genome-wide analysis of MDD yet conducted, its high prevalence means that the sample is still underpowered to detect genetic effects typical for complex traits, and it was unable to identify robust and replicable findings.
Increased burden of ultra-rare protein-altering variants among 4,877 individuals with schizophrenia
It was found that gene-disruptive and putatively protein-damaging URVs (but not synonymous URVs) were more abundant among individuals with schizophrenia than among controls, suggesting that synaptic dysfunction may mediate a large fraction of strong, individually rare genetic influences on schizophrenia risk.
Women with polycystic ovary syndrome are often depressed or anxious—A case control study
Fecundity of patients with schizophrenia, autism, bipolar disorder, depression, anorexia nervosa, or substance abuse vs their unaffected siblings.
The results suggest that strong selection exists against schizophrenia, autism, and anorexia nervosa and that these variants may be maintained by new mutations or an as-yet unknown mechanism.
Attitudes Toward Transsexualism in a Swedish National Survey
A majority supports the possibility for transsexuals to undergo sex reassignment; however, 63% thought that the individual should bear the expenses for it, and men and the older age group were found to hold a more restrictive view on these issues than women and the younger age group.
Mental illness, suicide and creativity: 40-year prospective total population study.
Long-Term Follow-Up of Transsexual Persons Undergoing Sex Reassignment Surgery: Cohort Study in Sweden
- C. Dhejne, P. Lichtenstein, M. Boman, A. Johansson, Niklas Långström, M. Landén
- Psychology, MedicinePloS one
- 22 February 2011
The findings suggest that sex reassignment, although alleviating gender dysphoria, may not suffice as treatment for transsexualism, and should inspire improved psychiatric and somatic care aftersex reassignment for this patient group.