• Publications
  • Influence
Clonal hematopoiesis and blood-cancer risk inferred from blood DNA sequence.
TLDR
Clonal hematopoiesis with somatic mutations is readily detected by means of DNA sequencing, is increasingly common as people age, and is associated with increased risks of hematologic cancer and death. Expand
Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs
TLDR
Empirical evidence of shared genetic etiology for psychiatric disorders can inform nosology and encourages the investigation of common pathophysiologies for related disorders. Expand
A mega-analysis of genome-wide association studies for major depressive disorder
TLDR
Although this is the largest genome-wide analysis of MDD yet conducted, its high prevalence means that the sample is still underpowered to detect genetic effects typical for complex traits, and it was unable to identify robust and replicable findings. Expand
Genome-wide association study identifies 30 Loci Associated with Bipolar Disorder
TLDR
The largest genome-wide association study to date, including 20,352 cases and 31,358 controls of European descent, with follow-up analysis of 881 sentinel variants at loci with P<1×10-4, achieves genome- wide significance including 18 novel loci, which provide potential new biological mechanisms for bipolar disorder. Expand
Women with polycystic ovary syndrome are often depressed or anxious—A case control study
TLDR
Clinicians treating women with PCOS should be aware that these women are a high risk group for common affective and anxiety disorders as well as suicide attempts, as verified by structured clinical assessments. Expand
Attitudes Toward Transsexualism in a Swedish National Survey
TLDR
A majority supports the possibility for transsexuals to undergo sex reassignment; however, 63% thought that the individual should bear the expenses for it, and men and the older age group were found to hold a more restrictive view on these issues than women and the younger age group. Expand
Increased burden of ultra-rare protein-altering variants among 4,877 individuals with schizophrenia
TLDR
It was found that gene-disruptive and putatively protein-damaging URVs (but not synonymous URVs) were more abundant among individuals with schizophrenia than among controls, suggesting that synaptic dysfunction may mediate a large fraction of strong, individually rare genetic influences on schizophrenia risk. Expand
Fecundity of patients with schizophrenia, autism, bipolar disorder, depression, anorexia nervosa, or substance abuse vs their unaffected siblings.
TLDR
The results suggest that strong selection exists against schizophrenia, autism, and anorexia nervosa and that these variants may be maintained by new mutations or an as-yet unknown mechanism. Expand
Polymorphisms of the androgen receptor gene and the estrogen receptor beta gene are associated with androgen levels in women.
TLDR
The results suggest that the serum levels of androgens in premenopausal women may be influenced by variants of the AR gene and the ER beta gene, respectively. Expand
Mental illness, suicide and creativity: 40-year prospective total population study.
TLDR
This study conducted a nested case-control study using longitudinal Swedish total population registries, where the occurrence of creative occupations in patients and their non-diagnosed relatives was compared to that of matched population controls and found an association between creative professions and first-degree relatives of patients with schizophrenia, bipolar disorder, anorexia nervosa, and for siblings of Patients with autism. Expand
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