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Regulation of cell fate decision of undifferentiated spermatogonia by GDNF.
TLDR
Transgenic loss-of-function and overexpression models show that the dosage of glial cell line-derived neurotrophic factor (GDNF), produced by Sertoli cells, regulates cell fate decisions of undifferentiated sperMatogonial cells that include the stem cells for spermatogenesis. Expand
Efficient in vivo manipulation of mouse genomic sequences at the zygote stage.
TLDR
A transgenic mouse line carrying the cre transgene under the control of the adenovirus EIIa promoter that targets expression of the Cre recombinase to the early mouse embryo is described and loxP-flanked DNA sequences are efficiently deleted. Expand
Hyperplasia of lymphatic vessels in VEGF-C transgenic mice.
TLDR
VEGF-C induces selective hyperplasia of the lymphatic vasculature, which is involved in the draining of interstitial fluid and in immune function, inflammation, and tumor metastasis, and may be of potential use in therapeutic lymphangiogenesis. Expand
Targeted oncogene activation by site-specific recombination in transgenic mice.
TLDR
Tumor formation resulted from large tumor-antigen activation via site-specific, Cre-mediated deletion of Stop sequences, and was confirmed through analysis of double-transgenic offspring developed lens tumors. Expand
Retarded Growth and Deficits in the Enteric and Parasympathetic Nervous System in Mice Lacking GFRα2, a Functional Neurturin Receptor
TLDR
It is shown that mice lacking functional GFR alpha2 coreceptor (Gfra2-/-) are viable and fertile but have dry eyes and grow poorly after weaning, presumably due to malnutrition. Expand
Osteoblast Recruitment and Bone Formation Enhanced by Cell Matrix–associated Heparin-binding Growth-associated Molecule (HB-GAM)
TLDR
It is shown here that heparin-binding growth-associated molecule (HB-GAM), an extracellular matrix–associated protein that enhances migratory responses in neurons, is prominently expressed in the cell matrices that act as target substrates for bone formation. Expand
Dopaminergic neuronal loss and motor deficits in Caenorhabditis elegans overexpressing human α‐synuclein
TLDR
This transgenic model in C. elegans, an invertebrate organism with excellent experimental resources for further genetic manipulation, may help facilitate dissection of pathophysiologic mechanisms of various synucleopathies. Expand
Overexpression of VEGF in Testis and Epididymis Causes Infertility in Transgenic Mice: Evidence for Nonendothelial Targets for VEGF
TLDR
Evidence that overexpression of VEGF in the testis and epididymis of transgenic mice under the mouse mammary tumor virus (MMTV) LTR promoter causes infertility is presented and it is suggested that the V EGF transgene has nonendothelial target cells in theTestis and that VEGf may regulate male fertility. Expand
Syndecan-3-Deficient Mice Exhibit Enhanced LTP and Impaired Hippocampus-Dependent Memory
TLDR
It is suggested that syndecan-3 acts as an important modulator of synaptic plasticity that influences hippocampus-dependent memory. Expand
The Neuroprotective Agent Memantine Induces Brain-Derived Neurotrophic Factor and trkB Receptor Expression in Rat Brain
TLDR
Data suggest that the neuroprotective properties of memantine could be mediated by the increased endogenous production of BDNF in the brain, which may open up new possibilities of pharmacologically regulating the expression of neurotrophic factors in thebrain. Expand
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