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SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes
We investigated SARS-CoV-2 potential tropism by surveying expression of viral entry-associated genes in single-cell RNA-sequencing data from multiple tissues from healthy human donors. We co-detectedExpand
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13 years of cultured limbal epithelial cell therapy: A review of the outcomes
The cornea is the clear tissue at the front of the eye which enables the transmission of light to the retina for normal vision. The surface of the cornea is composed of an epithelium which is renewedExpand
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Human Induced Pluripotent Stem Cell Lines Show Stress Defense Mechanisms and Mitochondrial Regulation Similar to Those of Human Embryonic Stem Cells
The generation of induced pluripotent stem cells (iPSC) has enormous potential for the development of patient‐specific regenerative medicine. Human embryonic stem cells (hESC) are able to defendExpand
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Expression and functional analysis of G1 to S regulatory components reveals an important role for CDK2 in cell cycle regulation in human embryonic stem cells
One of the characteristic features of human embryonic stem cells (hESCs) is the competence for self-renewal and pluripotency. To date, little is known about cell cycle regulation in these cells andExpand
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Isolation of Primordial Germ Cells from Differentiating Human Embryonic Stem Cells
Of all the cell types that can be obtained from the differentiation of embryonic stem cells, primordial germ cells are arguably the most fascinating, as they represent the in vitro completion of theExpand
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Downregulation of NANOG Induces Differentiation of Human Embryonic Stem Cells to Extraembryonic Lineages
The homeobox transcription factor Nanog has been proposed to play a crucial role in the maintenance of the undifferentiated state of murine embryonic stem cells. A human counterpart, NANOG, has beenExpand
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G1 to S phase cell cycle transition in somatic and embryonic stem cells
It is well known that G1 to S phase transition is tightly regulated by the expression and phosphorylation of a number of well‐characterized cyclins, cyclin‐dependent kinases and members of theExpand
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The role of PI3K/AKT, MAPK/ERK and NFkappabeta signalling in the maintenance of human embryonic stem cell pluripotency and viability highlighted by transcriptional profiling and functional analysis.
Understanding the molecular mechanism by which pluripotency is maintained in human embryonic stem cells (hESC) is important for the development of improved methods to derive, culture andExpand
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Efficient hematopoietic differentiation of human embryonic stem cells on stromal cells derived from hematopoietic niches.
Hematopoietic stem cells derived from human embryonic stem cells (hESCs) could provide a therapeutic alternative to bone marrow transplants, but the efficiency of currently available derivationExpand
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A role for NANOG in G1 to S transition in human embryonic stem cells through direct binding of CDK6 and CDC25A
In this study, we show that NANOG, a master transcription factor, regulates S-phase entry in human embryonic stem cells (hESCs) via transcriptional regulation of cell cycle regulatory components.Expand
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