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Molecular cytogenetic characterization of variant Philadelphia translocations in chronic myeloid leukemia: genesis and deletion of derivative chromosome 9.
The mechanisms for the formation of variant Philadelphia (Ph) translocations that occur in 5-10% of patients with chronic myeloid leukemia (CML) are not fully characterized. Studies on the prognosisExpand
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Familial hematological malignancies: ASXL1 gene investigation
AbstractPurposeFamilial aggregation among patients with several hematological malignancies has been revealed. This emphasizes the importance of genetic factors. Only few genes predisposing toExpand
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Molecular study of the perforin gene in familial hematological malignancies
Perforin gene (PRF1) mutations have been identified in some patients diagnosed with the familial form of hemophagocytic lymphohistiocytosis (HLH) and in patients with lymphoma. The aim of the presentExpand
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Contribution of Flow Cytometry to Acute Leukemia Classification in Tunisia
The precision of immunological characterization of leukemias was improved by a certain number of technical innovations, particularly hybridoma production and standardization, resulting in monoclonalExpand
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Bilateral tumoral infiltration of the Achilles tendons revealing chronic myelomonocytic leukemia.
Extrahematologic manifestations, such as symptoms of rheumatic disease, have been recorded in association with myelodysplastic syndromes, including chronic myelomonocytic leukemia (CMML). We reportExpand
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Maladie de Hodgkin associée à un sarcome de Kaposi et à une tuberculose des organes hématopoïétiques
L'association d'une maladie de Kaposi a une maladie de Hodgkin est rarement signalee. Nous rapportons l'observation d'une patiente agee de 57 ans, traitee pour maladie de Hodgkin et qui developpeExpand
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Aspects épidemiologiques, cliniques et thérapeutiques de la leucémie lymphoïde chronique: A propos de 120 cas
Nous avons etudie de maniere retrospective 120 cas de leucemie lymphoide chronique diagnostiques entre le ler janvier 1988 et le 31 decembre 1998. L'âge moyen de nos patients etait de 66 ans, 75%Expand
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[Gougerot-Sjögren syndrome disclosed by MALT lymphoma of the salivary glands. Report of 3 cases].
Sjögren's syndrome is characterized by an increased risk of developing non-Hodgkin's lymphoma. The lymphoma is most frequently extra-nodal, preferentially affecting the salivary gland: low-grade MALTExpand
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Leucémies aigues du sujet âgé: A propos de 40 cas
Entre 1989 et 1996 40 cas de LA ont ete diagnositiques (16 hommes et 24 femmes), âge moyen 65 ans (55 a 88 ans). L'hemogramme a trouve une hyperlrucocytose superieure a 30.109L dans 42% des cas. LeExpand