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Endogenous lipid- and peptide-derived anti-inflammatory pathways generated with glucocorticoid and aspirin treatment activate the lipoxin A4 receptor
Aspirin (ASA) and dexamethasone (DEX) are widely used anti-inflammatory agents yet their mechanism(s) for blocking polymorphonuclear neutrophil (PMN) accumulation at sites of inflammation remainsExpand
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A novel biological activity for galectin-1: inhibition of leukocyte-endothelial cell interactions in experimental inflammation.
Galectin-1 (Gal-1), the prototype of a family of beta-galactoside-binding proteins, has been shown to attenuate experimental acute and chronic inflammation. In view of the fact that endothelial cellsExpand
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Annexin 1 peptides protect against experimental myocardial ischemia‐reperfusion: analysis of their mechanism of action
Myocardial reperfusion injury is associated with the infiltration of blood‐borne polymorphonuclear leukocytes. We have previous described the protection afforded by annexin 1 (ANXA1) in anExpand
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Lipocortin 1 reduces myocardial ischemia‐reperfusion injury by affecting local leukocyte recruitment
We assessed here the effect of the glucocorticoid‐regulated protein lipocortin 1 (LC1) in a model of rat myocardial ischemia reperfusion. Treatment of animals with human recombinant LC1 at the end ofExpand
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Inhibitory Effects of TSG‐6 Link Module on Leukocyte–Endothelial Cell Interactions In Vitro and In Vivo
Objective: The authors investigated whether the anti‐inflammatory protein tumor necrosis factor (TNF)‐stimulated gene‐6 (TSG‐6) and its Link module (Link_TSG6) could affect the complex multistepExpand
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Neutrophil Elastase (NE)-Deficient Mice Demonstrate a Nonredundant Role for NE in Neutrophil Migration, Generation of Proinflammatory Mediators, and Phagocytosis in Response to Zymosan Particles In
Neutrophil elastase (NE) remains a controversial player in the process of leukocyte transmigration and much of this controversy stems from conflicting reports on the effects of NE inhibitors. TheExpand
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Analysis of the protection afforded by annexin 1 in ischaemia-reperfusion injury: focus on neutrophil recruitment.
Ischaemia-reperfusion injury underlies many of the most important cardiovascular diseases such as myocardial infarction, thrombotic stroke, embolic vascular occlusions and peripheral vascularExpand
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Development of novel activin-targeted therapeutics.
Soluble activin type II receptors (ActRIIA/ActRIIB), via binding to diverse TGF-β proteins, can increase muscle and bone mass, correct anemia or protect against diet-induced obesity. While exciting,Expand
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Interaction of human neutrophils with endothelial cells regulates the expression of endogenous proteins annexin 1, galectin‐1 and galectin‐3
Annexin 1 (ANXA1), galectin‐1 (Gal‐1) and galectin‐3 (Gal‐3) proteins have been identified as important mediators that promote or inhibit leukocyte migration. The expression of these proteins wasExpand
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