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Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen.
Gadd45 was found to bind to PCNA, a normal component of Cdk complexes and a protein involved in DNA replication and repair, establishing GADD45 as a link between the p53-dependent cell cycle checkpoint and DNA repair.
Disruption of p53 function sensitizes breast cancer MCF-7 cells to cisplatin and pentoxifylline.
A combination of CDDP and pentoxifylline is capable of synergistic and preferential killing of p53-defective tumor cells that do not readily undergo apoptosis and suggested that cancer cells are more vulnerable to G2 checkpoint abrogators.
Bcl-2 family proteins are essential for platelet survival
Data suggest that ABT-737 induces an apoptosis-like response in platelets that is distinct from platelet activation and results in enhanced clearance in vivo by the reticuloendothelial system.
Involvement of the p53 tumor suppressor in repair of u.v.-type DNA damage.
It is shown that disruption of normal p53 function in human colon carcinoma RKO cells with either the human papillomavirus E6 oncoprotein or a dominant-negative mutant p53 transgene results in reduced repair of u.v.-induced DNA damage and that this process is inducible by DNA damage.
Characterization of human Gadd45, a p53-regulated protein.
Vegetative incompatibility in the het-6 region of Neurospora crassa is mediated by two linked genes.
- M. L. Smith, O. Micali, S. P. Hubbard, N. Mir-Rashed, D. Jacobson, N. L. Glass
- 1 July 2000
Linkage analysis indicates that the 25-kbp un-24-het-6 region is inherited as a block, suggesting that a nonallelic interaction may occur between un- 24 and het-6 and possibly other loci within this region to mediate vegetative incompatibility in the het -6 region of N. crassa.
Antisense GADD45 expression results in decreased DNA repair and sensitizes cells to u.v.-irradiation or cisplatin.
- M. L. Smith, H. U. Kontny, Q. Zhan, A. Sreenath, P. O'Connor, A. Fornace
- 21 November 1996
The involvement of downstream effectors of the p53 pathway in the coordination of cell cycle arrest and DNA repair is suggested, as suggested by numerous reports linking p53 function to DNA repair.
Characterization of p21Cip1/Waf1 peptide domains required for cyclin E/Cdk2 and PCNA interaction.
The results provide an insight into domains of p21 that are involved in cyclin E/Cdk2 and PCNA interaction and suggest that a potential p21 dimerization domain may lie in the amino-terminus of p 21.
Coding assignments of double-stranded RNA segments of SA 11 rotavirus established by in vitro translation
The segmented double-stranded (ds) RNA genome of the simian rotavirus SA 11, after denaturation, can be translated in a cell-free protein synthesizing system and the probable gene-coding assignments of dsRNA segments 1 to 6 were determined.
Abrogation of p53 function affects gadd gene responses to DNA base-damaging agents and starvation.
Results indicate that p53 has a synergistic or cooperative role in these non-IR stress responses for both GADD45 and GADD153, and that this role is not mediated through identifiable p53-binding sites.