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Broad-spectrum antiviral that interferes with de novo pyrimidine biosynthesis
Compound A3 was identified in a high-throughput screen for inhibitors of influenza virus replication. It displays broad-spectrum antiviral activity, and at noncytotoxic concentrations it is shown toExpand
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Ebola Virus VP24 Binds Karyopherin α1 and Blocks STAT1 Nuclear Accumulation
ABSTRACT Ebola virus (EBOV) infection blocks cellular production of alpha/beta interferon (IFN-α/β) and the ability of cells to respond to IFN-α/β or IFN-γ. The EBOV VP35 protein has previously beenExpand
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A novel alliinase from onion roots. Biochemical characterization and cDNA cloning.
We have purified a novel alliinase (EC 4.4.1.4) from roots of onion (Allium cepa L.). Two isoforms with alliinase activity (I and II) were separated by concanavalin A-Sepharose and had molecularExpand
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Adenosine analogues as selective inhibitors of glyceraldehyde-3-phosphate dehydrogenase of Trypanosomatidae via structure-based drug design.
In our continuation of the structure-based design of anti-trypanosomatid drugs, parasite-selective adenosine analogues were identified as low micromolar inhibitors of glyceraldehyde-3-phosphateExpand
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Characterisation of the differences between hepatitis C virus genotype 3 and 1 glycoproteins
Sequence variation in the envelope E1 and E2 glycoproteins of hepatitis C virus (HCV) could account for differences in disease pathogenesis in patients infected with different genotypes. A cDNAExpand
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P–alkene bidentate ligands: an unusual ligand effect in Pd-catalysed Suzuki reactions
Abstract The versatile reagent bis(diphenylphosphino)benzaldehyde was used to prepare a variety of electronically and sterically varied ligands using Wittig or aldol methodology in high yields.Expand
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Recyclable Pd(OAc)2/Ligand/Al(OTf)3 Catalyst for the Homogeneous Methoxycarbonylation and Hydrocarboxylation Reactions of Phenylacetylene
The Pd-catalyzed methoxycarbonylation reaction of phenylacetylene was studied making use of various promoters, including aluminum triflate and several other acid-type promoters of this reaction. TheExpand
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Platinum complexes of malonate-derived monodentate phosphines and their application in the highly chemo- and regioselective hydroformylation of styrene
Abstract Neutral complexes of the formula PtCl2L2 (where L = diethyl 2-diphenylphosphino-malonate (1), diethyl 2-methyl-2-diphenylphosphinomalonate (2), dibenzyl 2-diphenylphosphinomalonate (3),Expand
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The amino acid sequence of the PKR-eIF2alpha phosphorylation homology domain of hepatitis C virus envelope 2 protein and response to interferon-alpha.
A region of the hepatitis C virus (HCV) envelope 2 protein, the protein kinase, PKR and early initiation factor 2alpha phosphorylation homology domain (PePHD), may be important in interferonExpand
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Platinum complexes of 2-diphenylphosphinobenzaldehyde-derived P-alkene ligands and their application in the hydroformylation of styrene
Abstract Neutral complexes of the formula PtCl2L2 (where L = diethyl 2-diphenylphosphino-benzylidene-malonate (1), diisopropyl 2-diphenylphosphino-benzylidene-malonate (2), di-tert-butylExpand
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