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Protective effect of Ginkgo biloba extract on liver damage by a single dose of CCl 4 in male rats
TLDR
The pretreatment with 4 mg/kg (p.o.) of Ginkgo biloba extract (GbE), for 5 days, prevented most of the damage caused by CCl 4: significantly decreased the serum activities of ALT and AST, compared to CCl4-treated rats; GbE partially prevented the increase of liver MDA and the decrease of albumin concentration. Expand
Acute renal failure induced by carbon tetrachloride in rats with hepatic cirrhosis.
TLDR
The present study suggests that in this model, damage typical of acute tubular necrosis ensues in cirrhotic rats, that might predispose to the development of acute renal failure when an individual with hepatic damage is exposed in acute way to chemical toxicants. Expand
Acidosis and weight loss are induced by cyclosporin A in uninephrectomized rats
TLDR
CyA induced a severe metabolic acidosis in uninephrectomized rats that was not compensated by the remaining kidney, in spite of the well-preserved compensatory weight gain of this organ. Expand
The Ginkgo biloba extract (GbE) protects the kidney from damage produced by a single and low dose of carbon tetrachloride in adult male rats.
TLDR
The main toxic effects produced by CCl4 were prevented by the GbE, probably due to their antioxidant properties and the inhibition of the main P450 isoenzyme (CYP2E1) that metabolize CCl 4. Expand
The flavonoid quercetin protects and prevents against potassium dichromate–induced systemic peroxidation of lipids and diminution in renal clearance of para-aminohippuric acid and inulin in the rat
TLDR
Treatment with quercetin protected and prevented against the nephrotoxicity caused by Cr in rats, and it was observed that a single dose of potassium dichromate resulted in both an increase of systemic peroxidation of lipids and a decrease of the renal clearance of para-aminohippuric acid and inulin. Expand
Renal damage induced by the pesticide methyl parathion in male Wistar rats
TLDR
Low doses of MP produced structural and functional damage to the proximal tubules of male rat kidney and significantly decreased renal GSH levels, increased GPx activity, as well as downregulated the mRNA expression of TNF-α and BAX. Expand
Renal failure during acute toxicity produced by tullidora ingestion (Karwinskia humboldtiana).
TLDR
Haemodynamic changes were observed with decrements of the glomerular filTration rate, renal plasma flow and filtration fraction during acute intoxication, and cloudy swelling and hydropic degeneration was seen 72 hr after intoxication. Expand
The ATP levels in kidneys and blood are mainly decreased by acute ingestion of tullidora (Karwinskia humboldtiana).
TLDR
The effects of Kh or 'tullidora' on energetic metabolism, a single dose of an oral preparation from the seed fruits was given to Wistar rats and might partially explain the acute effects and mortality observed in the Kh treated rats. Expand
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