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ELAM-1 mediates cell adhesion by recognition of a carbohydrate ligand, sialyl-Lex.
Cell adhesion by ELAM-1 is shown to be mediated by a carbohydrate ligand, sialyl-Lewis X (SLex; NeuAc alpha 2,3Gal beta 1,4(Fuc alpha 1,3)-GlcNAc-), a terminal structure found on cell-surface glycoprotein and glycolipid carbohydrate groups of neutrophils.
Brief report: recurrent severe infections caused by a novel leukocyte adhesion deficiency.
- Amos Etzioni, M. Frydman, R. Gershoni-baruch
- MedicineThe New England journal of medicine
- 17 December 1992
THE recruitment of neutrophils to sites of inflammation is initiated by the local production of bacteria-derived attractants, inflammatory cytokines, and other host-derived factors. These factors i...
CD62 and endothelial cell-leukocyte adhesion molecule 1 (ELAM-1) recognize the same carbohydrate ligand, sialyl-Lewis x.
- M. Polley, M. L. Phillips, J. Paulson
- Biology, ChemistryProceedings of the National Academy of Sciences…
- 15 July 1991
The results demonstrate that although the two LEC-CAMs differ in their biological activities by their distribution and mode of expression, they are capable of mediating cell adhesion by recognition of the same carbohydrate ligand.
Role of H1 receptors and P-selectin in histamine-induced leukocyte rolling and adhesion in postcapillary venules.
Observations suggest that histamine recruits rolling leukocytes and increases albumin leakage in postcapillary venules via H1 receptor activation, and histamine-induced recruitment of rolling Leukocytes is mediated in part by P-selectin expressed on the endothelial cell surface, which is consistent with the view that Histamine may act as a mediator of acute inflammatory reactions.
E-Selectin in Focal Cerebral Ischemia and Reperfusion in the Rat
- RuiLan Zhang, M. Chopp, A. Manning
- Biology, MedicineJournal of cerebral blood flow and metabolism…
- 1 November 1996
Findings provide the first direct evidence for the involvement of E- selectin in transient MCA occlusion in rats and suggest that the E-selectin may facilitate neutrophil adhesion and subsequent cerebral ischemic cell damage.
Role of P-selectin in total hepatic ischemia and reperfusion.
- F. J. García-Criado, L. Toledo-Pereyra, F. López-Neblina, M. L. Phillips, A. Páez-Rollys, K. Misawa
- Medicine, BiologyJournal of the American College of Surgeons
- 1 October 1995
Early modulation of the interaction between P-selectin and its ligand decreased neutrophil adhesion and migration and consequently diminished damage to the liver.
Neutrophil adhesion in leukocyte adhesion deficiency syndrome type 2.
- M. L. Phillips, B. Schwartz, J. Harlan
- Medicine, BiologyThe Journal of clinical investigation
- 1 December 1995
It is demonstrated that neutrophils from a LAD II patient bind minimally or not at all to recombinant E-selectin, purified platelet P- Selectin, or P- selectin expressed on histamine-activated human umbilical vein endothelial cells, but have normal levels of L-select in and CD11b/CD18 integrin.
Transcellular biosynthesis of lipoxin A4 during adhesion of platelets and neutrophils in experimental immune complex glomerulonephritis.
- A. Papayianni, C. Serhan, M. L. Phillips, H. Rennke, H. Brady
- Biology, MedicineKidney international
- 1 May 1995
Evidence is presented that lipoxin A4 is generated in rat kidneys during experimental immune complex-mediated glomerulonephritis in vivo, and that most lip toxin A4 generated in vivo was derived from transcellular biosynthetic pathways during platelet-neutrophil interactions.
A novel sialyl LewisX analog attenuates neutrophil accumulation and myocardial necrosis after ischemia and reperfusion.
- D. Lefer, D. Flynn, M. L. Phillips, M. Ratcliffe, A. Buda
- Medicine, BiologyCirculation
- 1 November 1994
There is strong evidence that treatment with a unique carbohydrate analog of SLeX, CY-1503, significantly reduces the degree of myocardial injury associated with coronary artery ischemia and reperfusion and the profound cardioprotection appears to be related to a reduction in PMN accumulation within the ischemic-reperfused myocardium.
Matrix‐enabled gene transfer for cutaneous wound repair
- L. Chandler, Chenglie Ma, M. L. Phillips
- Biology, EngineeringWound repair and regeneration : official…
- 1 November 2000
Enhanced enhancements of the tissue repair response have been achieved by combining matrix‐enabled gene transfer with molecular targeting, in which the DNA vector is conjugated to a growth factor ligand (basic fibroblast growth factor).