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Release from quiescence of CD34+ CD38- human umbilical cord blood cells reveals their potentiality to engraft adults.
TLDR
It is suggested that umbilical cord blood is a suitable source of cells for adult transplantation.
Release of early human hematopoietic progenitors from quiescence by antisense transforming growth factor beta 1 or Rb oligonucleotides
TLDR
The results are consistent with the model that autocrine production of TGF-beta negatively regulates the cycling status of early hematopoietic progenitors through interaction with the Rb gene product.
CSF‐1 control of C‐FMS expression in normal human bone marrow progenitors
TLDR
It is shown by in situ hybridization that IL3 allows the development, from CD34+ cells, of a subpopulation of immature progenitors which express the CSF‐1 receptor (c‐fms) mRNA.
An improved panning technique for the selection of CD34+ human bone marrow hematopoietic cells with high recovery of early progenitors.
TLDR
It is observed that a high degree of purity requires a thorough washing procedure so that cells not binding or weakly binding to CD34 antibodies are removed, and that high recoveries can be obtained if the adherent cells are efficiently detached by a 2-hour incubation in culture medium without added cytokines.
Additive effects of steel factor and antisense TGF-beta 1 oligodeoxynucleotide on CD34+ hematopoietic progenitor cells.
TLDR
In cord blood, some, but not all, of the progenitors that are maintained in quiescence by TGF-beta can be triggered into cycle by SF, and the absolute number of CFU-GEMMs found in the antisense T GF-beta plus SF cultures of cord blood was 4-fold higher than that found in comparable bone marrow cultures.
Effect of thermochemotherapy (combined cyclophosphamide and hyperthermia) given at various temperatures with or without glucose administration on a murine fibrosarcoma.
TLDR
The CY dose response curves at elevated temperatures were downward concave, which may indicate the presence of a CY- and heat-resistant cell population in the tumor, and implications in clinical hyperthermia were discussed.
Antimicrobial activity of synthetic all-D mastoparan M.
TLDR
Findings indicated the all-D mastoparan M could kill bacteria by disrupting cells by showing strong activity against gram-positive and gram-negative bacteria.
Human umbilical cord blood CD34+ cell purification with high yield of early progenitors.
TLDR
Human umbilical cord blood CD34+ cells were purified using a two-step procedure by elimination of the soybean agglutinin-binding cells and by a positive panning selection with a CD34 monoclonal antibody to suggest the possibility of purifying CD34+.
Fibrinogen potentiates the effect of interleukin-3 on early human hematopoietic progenitors.
TLDR
The results indicate that fibrinogen potentiates the effect of IL-3 on primitive hematopoietic progenitors and suggest that the mitogenic effect of fibr inogen could be mediated via a specific mitogenic receptor that does not belong to the integrin family.
A sub-population of high proliferative potential-quiescent human mesenchymal stem cells is under the reversible control of interferon α/β
TLDR
It is demonstrated that control and activated MSCs express ST3GAL3, a sialyltransferase necessary to produce the embryonic antigens SSEA-3 and -4, which indicates that the use of 64G12, which rapidly recruits a higher number of primitive cells, might increase amplification safety for cell therapy.
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