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Notch controls embryonic Schwann cell differentiation, postnatal myelination and adult plasticity
Notch signaling is central to vertebrate development, and analysis of Notch has provided important insights into pathogenetic mechanisms in the CNS and many other tissues. However, surprisinglyExpand
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New insights on schwann cell development
In the peripheral nervous system, Schwann cells are glial cells that are in intimate contact with axons throughout development. Schwann cells generate the insulating myelin sheath and provide vitalExpand
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Expression of Laminin Receptors in Schwann Cell Differentiation: Evidence for Distinct Roles
Schwann cells require laminin-2 throughout nerve development, because mutations in the α2 chain in dystrophic mice interfere with sorting of axons before birth and formation of myelin internodesExpand
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Both Laminin and Schwann Cell Dystroglycan Are Necessary for Proper Clustering of Sodium Channels at Nodes of Ranvier
Nodes of Ranvier are specialized axonal domains, at which voltage-gated sodium channels cluster. How axons cluster molecules in discrete domains is mostly unknown. Both axons and glia probablyExpand
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α6β4 Integrin and Dystroglycan Cooperate to Stabilize the Myelin Sheath
Schwann cells integrate signals deriving from the axon and the basal lamina to myelinate peripheral nerves. Integrin α6β4 is a laminin receptor synthesized by Schwann cells and displayed apposed toExpand
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Schwann Cell-Specific Ablation of Laminin γ1 Causes Apoptosis and Prevents Proliferation
To investigate the function of laminin in peripheral nerve development, we specifically disrupted the laminin γ1 gene in Schwann cells. Disruption of laminin γ1 gene expression resulted in depletionExpand
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TACE (ADAM17) inhibits Schwann cell myelination
Tumor necrosis factor-α–converting enzyme (TACE; also known as ADAM17) is a proteolytic sheddase that is responsible for the cleavage of several membrane-bound molecules. We report that TACE cleavesExpand
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Schwann cells expressing dismutase active mutant SOD1 unexpectedly slow disease progression in ALS mice
Neurodegeneration in an inherited form of ALS is non-cell-autonomous, with ALS-causing mutant SOD1 damage developed within multiple cell types. Selective inactivation within motor neurons of anExpand
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Loss of Mtmr2 Phosphatase in Schwann Cells But Not in Motor Neurons Causes Charcot-Marie-Tooth Type 4B1 Neuropathy with Myelin Outfoldings
Mutations in MTMR2, the myotubularin-related 2 gene, cause autosomal recessive Charcot-Marie-Tooth type 4B1 (CMT4B1). This disorder is characterized by childhood onset of weakness and sensory loss,Expand
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YAP and TAZ control peripheral myelination and the expression of laminin receptors in Schwann cells
Myelination is essential for nervous system function. Schwann cells interact with neurons and the basal lamina to myelinate axons using known receptors, signals and transcription factors. InExpand
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