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- Publications
- Influence
Identification of Novel TGF-β/Smad Gene Targets in Dermal Fibroblasts using a Combined cDNA Microarray/Promoter Transactivation Approach*
- F. Verrecchia, M. L. Chu, A. Mauviel
- Biology, Medicine
- The Journal of Biological Chemistry
- 18 May 2001
Despite major advances in the understanding of the intimate mechanisms of transforming growth factor-β (TGF-β) signaling through the Smad pathway, little progress has been made in the identification… Expand
Structure and expression of fibulin-2, a novel extracellular matrix protein with multiple EGF-like repeats and consensus motifs for calcium binding
- T. Pan, T. Sasaki, R. Zhang, R. Fässler, R. Timpl, M. L. Chu
- Biology, Medicine
- The Journal of cell biology
- 1 December 1993
A new protein, fibulin-2, was predicted from sequence analysis of cDNA clones obtained from a mouse fibroblast library. This protein consists of a 1195-residue polypeptide preceded by a 26-residue… Expand
Role of mesenchymal nidogen for epithelial morphogenesis in vitro.
Recent biochemical studies suggested that the extracellular matrix protein nidogen is a binding molecule linking together basement membrane components. We studied its expression and role during… Expand
Perinatal Lethality and Endothelial Cell Abnormalities in Several Vessel Compartments of Fibulin-1-Deficient Mice
- G. Kostka, R. Giltay, +4 authors M. L. Chu
- Biology, Medicine
- Molecular and Cellular Biology
- 15 October 2001
ABSTRACT The extracellular matrix protein fibulin-1 is a distinct component of vessel walls and can be associated with other ligands present in basement membranes, microfibrils, and elastic fibers.… Expand
Cloning and characterization of five overlapping cDNAs specific for the human pro alpha 1(I) collagen chain.
- M. L. Chu, J. Myers, M. Bernard, J. Ding, F. Ramirez
- Biology, Medicine
- Nucleic acids research
- 11 October 1982
We report the cloning of five overlapping cDNAs bearing sequences specific for the human pro alpha 1(I) collagen chain. Poly-A RNA enriched for collagen sequences was purified from normal human… Expand
Amino acid sequence of mouse nidogen, a multidomain basement membrane protein with binding activity for laminin, collagen IV and cells.
- K. Mann, R. Deutzmann, +6 authors M. L. Chu
- Biology, Medicine
- The EMBO journal
- 1 January 1989
The whole amino acid sequence of nidogen was deduced from cDNA clones isolated from expression libraries and confirmed to approximately 50% by Edman degradation of peptides. The protein consists of… Expand
Activation of collagen gene expression in keloids: co-localization of type I and VI collagen and transforming growth factor-beta 1 mRNA.
- J. Peltonen, L. L. Hsiao, +5 authors J. Uitto
- Biology, Medicine
- The Journal of investigative dermatology
- 1 August 1991
Untreated, clinically active keloids were examined as model system to study the spatial expression of extracellular matrix and transforming growth factor-beta 1 (TGF-beta 1) genes in fibrotic skin… Expand
Mapping of nidogen binding sites for collagen type IV, heparan sulfate proteoglycan, and zinc.
- D. Reinhardt, K. Mann, +4 authors R. Timpl
- Chemistry, Medicine
- The Journal of biological chemistry
- 25 May 1993
Recombinant nidogen fragments comprising the globular domains G1 plus G2, the rod-like domain, and the rod connected to the globe G3 were prepared from the culture media of transfected human cell… Expand
Fibulin‐2 expression marks transformed mesenchymal cells in developing cardiac valves, aortic arch vessels, and coronary vessels
- T. Tsuda, H. Wang, R. Timpl, M. L. Chu
- Biology, Medicine
- Developmental dynamics : an official publication…
- 1 September 2001
Previous studies showed that extracellular matrix protein, fibulin‐2, is expressed during epithelial–mesenchymal transformation in the endocardial cushion matrix during embryonic heart development.… Expand
Fibrillin-1 and Fibulin-2 Interact and Are Colocalized in Some Tissues*
- D. Reinhardt, T. Sasaki, +5 authors L. Sakai
- Chemistry, Medicine
- The Journal of Biological Chemistry
- 9 August 1996
Microfibrils 10-12 nm in diameter are found in elastic and non-elastic tissues with fibrillin as a major component. Little is known about the supramolecular structure of these microfibrils and the… Expand