M. L. Chu

Publications129
h-index57
Citations9,586
Highly Influential Citations192
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Identification of Novel TGF-β/Smad Gene Targets in Dermal Fibroblasts using a Combined cDNA Microarray/Promoter Transactivation Approach*
Despite major advances in the understanding of the intimate mechanisms of transforming growth factor-β (TGF-β) signaling through the Smad pathway, little progress has been made in the identification… Expand
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Structure and expression of fibulin-2, a novel extracellular matrix protein with multiple EGF-like repeats and consensus motifs for calcium binding
A new protein, fibulin-2, was predicted from sequence analysis of cDNA clones obtained from a mouse fibroblast library. This protein consists of a 1195-residue polypeptide preceded by a 26-residue… Expand
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Role of mesenchymal nidogen for epithelial morphogenesis in vitro.
Recent biochemical studies suggested that the extracellular matrix protein nidogen is a binding molecule linking together basement membrane components. We studied its expression and role during… Expand
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Perinatal Lethality and Endothelial Cell Abnormalities in Several Vessel Compartments of Fibulin-1-Deficient Mice
ABSTRACT The extracellular matrix protein fibulin-1 is a distinct component of vessel walls and can be associated with other ligands present in basement membranes, microfibrils, and elastic fibers.… Expand
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Cloning and characterization of five overlapping cDNAs specific for the human pro alpha 1(I) collagen chain.
We report the cloning of five overlapping cDNAs bearing sequences specific for the human pro alpha 1(I) collagen chain. Poly-A RNA enriched for collagen sequences was purified from normal human… Expand
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Amino acid sequence of mouse nidogen, a multidomain basement membrane protein with binding activity for laminin, collagen IV and cells.
The whole amino acid sequence of nidogen was deduced from cDNA clones isolated from expression libraries and confirmed to approximately 50% by Edman degradation of peptides. The protein consists of… Expand
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Activation of collagen gene expression in keloids: co-localization of type I and VI collagen and transforming growth factor-beta 1 mRNA.
Untreated, clinically active keloids were examined as model system to study the spatial expression of extracellular matrix and transforming growth factor-beta 1 (TGF-beta 1) genes in fibrotic skin… Expand
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Mapping of nidogen binding sites for collagen type IV, heparan sulfate proteoglycan, and zinc.
Recombinant nidogen fragments comprising the globular domains G1 plus G2, the rod-like domain, and the rod connected to the globe G3 were prepared from the culture media of transfected human cell… Expand
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Fibulin‐2 expression marks transformed mesenchymal cells in developing cardiac valves, aortic arch vessels, and coronary vessels
Previous studies showed that extracellular matrix protein, fibulin‐2, is expressed during epithelial–mesenchymal transformation in the endocardial cushion matrix during embryonic heart development.… Expand
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Fibrillin-1 and Fibulin-2 Interact and Are Colocalized in Some Tissues*
Microfibrils 10-12 nm in diameter are found in elastic and non-elastic tissues with fibrillin as a major component. Little is known about the supramolecular structure of these microfibrils and the… Expand
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