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Antileishmanial Activity of the Hydroalcoholic Extract of Miconia langsdorffii, Isolated Compounds, and Semi-Synthetic Derivatives
The in vitro activity of the crude hydroalcoholic extract of the aerial parts of Miconia langsdorffii Cogn. was evaluated against the promastigote forms of L. amazonensis, the causative agent ofExpand
Antimicrobial Activity of the Extract and Isolated Compounds from Baccharis dracunculifolia D. C. (Asteraceae)
TLDR
The results showed that the leaves extract of B. dracunculifolia, similar to the GPE, displays antimicrobial activity, which may be related to the effect of several compounds present in the crude extract. Expand
Curcumin-loaded into PLGA nanoparticles
TLDR
This study marks the first time that schistosomicidal activity has been reported for curcumin-loaded PLGA nanoparticles. Expand
In vitro antiparasitic activity and chemical composition of the essential oil obtained from the fruits of Piper cubeba.
TLDR
The essential oil reported that the essential oil obtained by steam distillation of the fruits of Piper cubeba is active against Schistosoma mansoni is investigated to determine the compounds responsible for the observed activities, as well as its mechanism of action. Expand
A comparative study of the modulatory effects of (-)-cubebin on the mutagenicity/recombinogenicity induced by different chemical agents.
TLDR
The findings indicate an absence of a CUB-mediated genotoxic effect at the concentrations tested and reveal that CUB significantly reduced the frequency of MN induced by DXR, with a mean reduction of 63.88%. Expand
The lignan (-)-hinokinin displays modulatory effects on human monoamine and GABA transporter activities.
TLDR
The results suggest that 2 may serve as a tool to develop new therapeutic drugs for ADHD and anxiety that target the DAT, NET, and GAT-1 transporters. Expand
In Vitro Schistosomicidal Activity of Some Brazilian Cerrado Species and Their Isolated Compounds
TLDR
Biological results indicated that crude extracts of R. montana, S. vinosa, and M. langsdorffii and some n-hexane and EtOAc fractions of this species were able to induce worm death to some extent, and lupane-type triterpenes and flavonoid monoglycosides should be considered for further antiparasites studies. Expand
In vivo infection by Trypanosoma cruzi: a morphometric study of tissue changes in mice
TLDR
The cytotoxicity assays demonstrated that (−)-cubebin and (−)-hinokinin do not display toxicity and are promising therapeutic agents and could be used in future clinical studies concerning treatment of the Chagas disease. Expand
Antibacterial Activity of the Essential Oil from Rosmarinus offi cinalis and its Major Components against Oral Pathogens
TLDR
This is the first report on antimicrobial activity of the major components of rosemary oil against oral pathogens and the pure major compounds were more active than the essential oil. Expand
(-)-Hinokinin causes antigenotoxicity but not genotoxicity in peripheral blood of Wistar rats.
TLDR
The present study shows that (-)-hinokinin not only has no genotoxic effect, but is also effective in reducing the chromosome damage induced by the chemotherapeutic agent doxorubicin (DXR). Expand
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