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A review on the dietary flavonoid kaempferol.
TLDR
The distribution of ka Kempferol in the plant kingdom and its pharmacological properties are reviewed and the pharmacokinetics and safety of kaempferol are analyzed to help understand the health benefits of kaEMPferol-containing plants and to develop this flavonoid as a possible agent for the prevention and treatment of some diseases. Expand
Distribution and biological activities of the flavonoid luteolin.
TLDR
The ability of luteolin to inhibit angiogenesis, to induce apoptosis, to prevent carcinogenesis in animal models, to reduce tumor growth in vivo and to sensitize tumor cells to the cytotoxic effects of some anticancer drugs suggests that this flavonoid has cancer chemopreventive and chemotherapeutic potential. Expand
Anticancer and carcinogenic properties of curcumin: considerations for its clinical development as a cancer chemopreventive and chemotherapeutic agent.
TLDR
In vitro and in vivo cancer-related activities of curcumin are analyzed and it is discussed that they are linked to its known antioxidant and pro-oxidant properties and several considerations that may help developCurcumin as an anticancer agent are discussed. Expand
Dual role of hydrogen peroxide in cancer: possible relevance to cancer chemoprevention and therapy.
TLDR
The present report discusses that the high levels of H( 2)O(2) commonly observed in cancer cells may be essential for cancer development; these high levels, however, seem almost incompatible with cell survival and may make cancer cells more susceptible to H(2)-induced cell death than normal cells. Expand
Curcumin induces high levels of topoisomerase I- and II-DNA complexes in K562 leukemia cells.
TLDR
Overall, this work shows that curcumin is capable of inducing topo-DNA complexes in cells with both topo I and topo II and increases the evidence suggesting that this dietary agent has potential to be tested in cancer chemotherapy. Expand
Digitoxin as an anticancer agent with selectivity for cancer cells: possible mechanisms involved
TLDR
It is proposed that the inhibition of glycolysis may be a key mechanism by which this natural product selectively targets cancer cells in patients with cancer. Expand
Cytotoxic effect of Plantago spp. on cancer cell lines.
TLDR
Luteolin-7-O-beta-glucoside is identified as major flavonoid present in most of the Plantago species, and topoisomerase-mediated DNA damage might be a possible mechanism by which flavonoids of Plantago exert their cytotoxicity potential. Expand
The dark side of curcumin
TLDR
The purpose of this letter is to briefly review the negative properties of curcumin so that they can be balanced against its beneficial effects and suggests that the therapeutic potential of oralCurcumin is limited. Expand
Pro-oxidant natural products as anticancer agents.
TLDR
An overview of natural products with pro-oxidant and anticancer activities, with special focus on plant secondary metabolites, and discusses their possible use as cancer chemotherapeutic agents. Expand
A New View of Carcinogenesis and an Alternative Approach to Cancer Therapy
TLDR
Evidence that tumor cells, in addition to acquiring a complex array of genetic changes, develop an alteration in the metabolism of oxygen is reviewed, suggesting that the altered oxygen metabolism of cancer cells is not subject to the high genetic variability of tumors and may therefore be a more reliable target for cancer therapy. Expand
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