Thiophene derivatives as new mechanism-based inhibitors of cytochromes P-450: inactivation of yeast-expressed human liver cytochrome P-450 2C9 by tienilic acid.
- M. López-Garcı́a, P. Dansette, D. Mansuy
- Biology, ChemistryBiochemistry
- 11 January 1994
TA exhibited all of the characteristics of a mechanism-based inactivator for P 450 2C9 and 2C10 enzymes and could be a starting point for the appearance of anti-P450 2C antibodies detected in patients treated with TA and suffering from immunoallergic hepatitis.
Endogenous nitric oxide is responsible for the early loss of P450 in cultured rat hepatocytes
- M. López-Garcı́a
- Biology, MedicineFEBS Letters
- 6 November 1998
Differential sensitivity of rat hepatocyte CYP isoforms to self‐generated nitric oxide
- S. Vernia, Philippe Beaune, J. Coloma, M. López-Garcı́a
- BiologyFEBS Letters
- 12 January 2001
Peroxynitrite generated from constitutive nitric oxide synthase mediates the early biochemical injury in short‐term cultured hepatocytes
- M. López-Garcı́a, S. Sanz-González
- BiologyFEBS Letters
- 21 January 2000
Kinetics of tienilic acid bioactivation and functional generation of drug-protein adducts in intact rat hepatocytes.
- M. López-Garcı́a, P. Dansette, J. Coloma
- Biology, MedicineBiochemical Pharmacology
- 5 December 2005
Nitric oxide-scavenging properties of some chalcone derivatives.
- F. Herencia, M. López-Garcı́a, A. Úbeda, M. Ferrándiz
- BiologyNitric oxide
- 1 March 2002
Assessment of the NO-scavenging capacity of three chalcone derivatives in a competitive assay with HbO(2) suggests an additional action of these compounds on NO regulation.
Involvement of peroxynitrite on the early loss of p450 in short-term hepatocyte cultures.
- S. Vernia, S. Sanz-González, M. López-Garcı́a
- BiologyAdvances in Experimental Medicine and Biology
- 2001
Results support the view that PN--while not affecting cell viability and monolayer development--is the main species likely responsible for the early loss of P450 in short-term cultured hepatocytes.