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Interleukin‐19 protects mice from innate‐mediated colonic inflammation
Background: Inflammatory bowel disease (IBD) results from the chronic dysregulation of the mucosal immune system and the aberrant activation of both the innate and the adaptive immune responses. WeExpand
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PACAP provides colonic protection against dextran sodium sulfate induced colitis
Pituitary adenylate cyclase‐activating polypeptide (PACAP) plays a crucial role in immunity and inflammation. Our aim was to obtain insight in the role of PACAP in experimental colitis in mice andExpand
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PPARα contributes to colonic protection in mice with DSS-induced colitis.
Inflammatory bowel disease (IBD) is characterized by repeated chronic inflammation of the gastrointestinal tract. We have used the complementary model of colonic inflammation to examine the roles ofExpand
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The Myelin Vacuolation (mv) Rat with a Null Mutation in the Attractin Gene
We recently found a spontaneous tremor mutant in an outbred colony of Sprague-Dawley rats. The tremor behavior was exhibited from around 3 weeks of age and inherited as an autosomal recessive trait.Expand
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Identification of the rat Rex mutation as a 7-bp deletion at splicing acceptor site of the Krt71 gene.
The rat autosomal dominant Rex (Re) mutation on chromosome 7 causes curly hair in Re/+ and hair loss in Re/Re rats. Histopathologically, the Re/+ rat showed dilatation of the hair follicle and hairsExpand
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Development of Sperm Granulomas in the Epididymides of L-Cysteine-Treated Rats
We investigated the histopathological effects of excess L-cysteine on the male rat reproductive tract during sexual maturation. Male 6-week-old Sprague—Dawley rats were injected intraperitoneallyExpand
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Expression of a Chemorepellent Factor, Slit2, in Peripheral Nerve Regeneration
The expression of mRNA for chemorepellent factors slit1 and slit2 in rat peripheral nerve regeneration was examined. The mRNA of slit2 increased when the continuity of basal lamina tubes wasExpand
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Urinary metabolic fingerprinting for amiodarone-induced phospholipidosis in rats using FT-ICR MS.
In the research and development for new therapeutic compounds, there has been a focus on detecting the changes of metabolites induced by drug administration and finding surrogate markers to assessExpand
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Participation of Functionally Different Macrophage Populations and Monocyte Chemoattractant Protein-1 in Early Stages of Thioacetamide-induced Rat Hepatic Injury
Macrophages are crucial in hepatic fibrogenesis. In acute hepatic necrosis induced in rats by a single injection of 300 mg/kg body weight (BW) of thioacetamide (TAA), macrophage properties wereExpand
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Immunohistochemical Characterization of Macrophages and Myofibroblasts in α-Naphthylisothiocyanate (ANIT)–Induced Bile Duct Injury and Subsequent Fibrogenesis in Rats
To investigate pathogenesis of post–bile duct (BD) injury fibrosis, interlobular BD epithelial injury was induced in male F344 rats by a single IP injection of α-naphthylisothiocyanate (75 mg/kg bodyExpand
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