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Characterization of platelet dysfunction after trauma
BACKGROUND The increased morbidity and mortality associated with coagulopathy and thrombocytopenia after trauma are well described. However, few studies have assessed platelet function after injury.Expand
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Coagulopathy after traumatic brain injury.
Traumatic brain injury has long been associated with abnormal coagulation parameters, but the exact mechanisms underlying this phenomenon are poorly understood. Coagulopathy after traumatic brainExpand
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Extracellular histone release in response to traumatic injury: Implications for a compensatory role of activated protein C
BACKGROUND Tissue injury leads to the release of DAMPs (damage-associated molecular patterns) that may drive a sterile inflammatory response; however, the role of extracellular histone levels afterExpand
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Spinal cord injury: outcomes of ventilatory weaning and extubation.
BACKGROUND Spinal cord injury (SCI) carries potentially devastating respiratory implications depending on injury level. Optimal strategies for mechanical ventilation in this setting remain poorlyExpand
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Criteria for empiric treatment of hyperfibrinolysis after trauma
BACKGROUND Recent studies identify a survival benefit from the administration of antifibrinolytic agents in patients with severe injury and trauma. However, identification of hyperfibrinolysisExpand
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Epidural analgesia for blunt thoracic injury--which patients benefit most?
INTRODUCTION Epidural analgesia for blunt thoracic injury has been demonstrated to be beneficial for pulmonary function, analgesia, and subjective pain; however the optimal patient selection andExpand
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Mechanical ventilation weaning and extubation after spinal cord injury: A Western Trauma Association multicenter study
BACKGROUND Respiratory failure after acute spinal cord injury (SCI) is well recognized, but data defining which patients need long-term ventilator support and criteria for weaning and extubation areExpand
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Emergency preservation and resuscitation for cardiac arrest from trauma.
The advent of cardiopulmonary resuscitation (CPR) revolutionized the care of patients with cardiac arrest, now allowing survival of up to 30% after out-of-hospital arrest due to arrhythmia; however,Expand
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Inducing Acute Traumatic Coagulopathy In Vitro: The Effects of Activated Protein C on Healthy Human Whole Blood
Introduction Acute traumatic coagulopathy has been associated with shock and tissue injury, and may be mediated via activation of the protein C pathway. Patients with acute traumatic coagulopathyExpand
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A structured communication adolescent guide (SCAG): assessment of reliability and validity.
PURPOSE To assess the reliability and validity of a Structured Communication Adolescent Guide (SCAG) in an undergraduate medical education setting using trained adolescent raters. METHOD The SCAGExpand
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