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Induction of miR-21 by Retinoic Acid in Estrogen Receptor-positive Breast Carcinoma Cells
It is found that pro-oncogenic miR-21 is selectively induced by ATRA in ERα+ cells, and three novel direct mi R-21 targets are identified: the pro-inflammatory cytokine IL1B, the adhesion molecule ICAM-1 and PLAT, the tissue-type plasminogen activator. Expand
Regulation and Biochemistry of Mouse Molybdo-flavoenzymes
It is demonstrated that CD-1, C57BL/6, 129/Sv, and other mouse strains synthesize high levels of AOH1 in the liver and AOH2 in the skin, and that neither enzyme is involved in the in vivo biotransformation of acetaldehyde. Expand
Isolation and characterization of the human aldehyde oxidase gene: conservation of intron/exon boundaries with the xanthine oxidoreductase gene indicates a common origin.
The results strongly suggest that the AO and XOR genetic loci arose as the consequence of a duplication event, and Southern blot analysis conducted on genomic DNA from various animal species with specific cDNA probes indicates that theAO gene is less conserved than the XOR gene during evolution. Expand
Role of the Molybdoflavoenzyme Aldehyde Oxidase Homolog 2 in the Biosynthesis of Retinoic Acid: Generation and Characterization of a Knockout Mouse
The data obtained for this knockout model indicate a significant role of AOH2 in the local synthesis and biodisposition of endogenous retinoids in the Harderian gland and skin. Expand
Cellular and molecular determinants of all-trans retinoic acid sensitivity in breast cancer: Luminal phenotype and RARα expression
Gen sets of predictive potential which are associated with ATRA sensitivity in breast cancer cell lines are defined and validated in short‐term tissue cultures of Luminal/ER+ and triple‐negative tumors and perturbations in the transcriptomic profiles afforded by ATRA are determined. Expand
Structure and evolution of vertebrate aldehyde oxidases: from gene duplication to gene suppression
This work cloned the cDNAs encoding the AOX proteins of guinea pig and cynomolgus monkeys, two unique species as to the evolution of this enzyme family, and identifies chimeric RNAs from the human AOX3 and AOx3L1 pseudogenes with potential to encode a novel microRNA. Expand
Molecular cloning of the cDNA coding for mouse aldehyde oxidase: tissue distribution and regulation in vivo by testosterone.
In the liver of male animals, despite similar amounts of AO mRNA, the levels of the AO enzyme and corresponding polypeptide are significantly higher than those in female animals. Expand
MicroRNA networks regulated by all-trans retinoic acid and Lapatinib control the growth, survival and motility of breast cancer cells
This study demonstrates that HIPK2-kinase and the PLCXD1-phospholipase-C are novel targets of miR-193a-5p/miR-210-3p and miR -575/mi R-1225- 5p, respectively, and some of these effects are of general significance. Expand
The xanthine oxidoreductase gene: structure and regulation.
Purification, cDNA Cloning, and Tissue Distribution of Bovine Liver Aldehyde Oxidase (*)
The tissue distribution of the bovine aldehyde oxidase protein and corresponding mRNA was determined and the amino acid sequence deduced from the cDNA shows significant similarity with that of xanthine dehydrogenases from various sources. Expand