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Efficacy and safety of immunotherapy for allergies to Alternaria alternata in children.
Allergen-specific immunotherapy with standardized A alternata extract reduces symptoms of asthma and rhinoconjunctivitis in children and adolescents without serious side effects. Expand
Solution-engineered palladium nanoparticles: model for health effect studies of automotive particulate pollution.
The studies demonstrate cellular uptake of Pd nanoparticles only in PBEC, as determined by TEM, with pronounced and dose-dependent effects on cellular secretion of soluble biomarkers in both cell types and a decreased responsiveness of human epithelial cells to the pro-inflammatory cytokine TNF-α. Expand
Increased YKL-40 and Chitotriosidase in Asthma and Chronic Obstructive Pulmonary Disease.
Genotype and age strongly affected both YKL-40 and chitotriosidase activity, but associations with disease remained following adjustment for these factors, and these substances are supported as being relatively steroid-insensitive, non-T-helper cell type 2-type biomarkers distinctly related to chronic inflammatory disease processes. Expand
National and regional asthma programmes in Europe
The three evaluated programmes show that, thanks to rigorous efforts, it is possible to improve patients' quality of life and reduce hospitalisation, asthma mortality, sick leave and disability pensions and the direct and indirect costs can be significantly reduced. Expand
Frequent exacerbators – a distinct phenotype of severe asthma
Exacerbations represent a major source of morbidity and mortality in asthma and are a prominent feature of poorly controlled, difficult‐to‐treat disease.
Lipoxin A4 generation is decreased in aspirin‐sensitive patients in lysine‐aspirin nasal challenge in vivo model
The aim of this study was to determine lipoxin A4 and leukotriene C4 levels in nasal lavages after intranasal challenge with aspirin in aspirin intolerant (AIA) in comparison to aspirin tolerant (ATA) asthmatics and after allergen challenge in patients suffering from allergic rhinitis. Expand
Transcriptome analysis reveals upregulation of bitter taste receptors in severe asthmatics
Specific gene expression patterns were observed in children with severe, therapy-resistant asthma and the increased expression of bronchodilatory TAS2Rs suggests a new target for the treatment of asthma. Expand
Stability of phenotypes defined by physiological variables and biomarkers in adults with asthma
The stability of phenotypes defined either by biomarkers or by physiological variables was assessed by repeated measures over 1 year in the Pan‐European BIOAIR cohort of adult asthmatics. Expand
Mediators of inflammation in nasal lavage from aspirin intolerant patients after aspirin challenge.
It is found that persistent inflammation in AIA patients is characterized by overproduction of MCP-3 and RANTES, which suggest that those mediators are involved in chronic rather than acute phase of ASA induced inflammation. Expand
Long-Term Deterioration of Lung Function in Asthmatic Outpatients
The results of this large cohort study show that asthmatic patients develop a progressive decline in pulmonary function correlated with age, sex, duration of asthma and asthma severity. Expand