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Solid-phase synthesis of 16 potent (selective and nonselective) in vivo antagonists of oxytocin.
We describe the synthesis and some pharmacological properties of 16 new in vivo antagonists of oxytocin. These are based on modifications of three peptides: A, B, and C. A is our previously reportedExpand
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No requirement of cyclic conformation of antagonists in binding to vasopressin receptors
Early reports that acyclic analogues of oxytocin and vasopressin (AVP) have drastically reduced agonistic activities established as dogma that an intact hexapeptide ring structure is essential forExpand
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C-terminal deletions in agonistic and antagonistic analogues of vasopressin that improve their specificities for antidiuretic (V2) and vasopressor (V1) receptors.
We report the solid-phase synthesis of 12 desGly and 12 desGly(NH2) analogues of arginine-vasopressin (AVP), two highly selective antidiuretic (V2) agonists, four vasopressor (V1) antagonists, andExpand
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Design of potent and selective linear antagonists of vasopressor (V1-receptor) responses to vasopressin.
We report the solid-phase synthesis of 21 linear analogues of A and D, two nonselective antagonists of the vasopressor (V1) and antidiuretic (V2) responses to arginine vasopressin (AVP). A isExpand
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Novel linear antagonists of the antidiuretic (V2) and vasopressor (V1) responses to vasopressin.
We report the solid phase synthesis of a series of 16 linear analogues of the cyclic antagonist of the antidiuretic (V2) and the vasopressor (V1) responses to arginine vasopressin (AVP),Expand
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Peptides from multiple regions of the lectin domain of P-selectin inhibiting neutrophil adhesion.
The selectins are a family of three structurally related glycoproteins that are integral components of leukocyte adhesion to the vascular endothelium. Their involvement in the recruitment andExpand
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Biological activity of TRH thionalogue and its diastereoisomers.
Binding affinity and TSH-releasing activity of [Prot3] TRH analogue (L-pyroglutamyl-L-histidyl-L-proline thioamide), TRH and their LDL and LLD diastereoisomers were compared in rats. Binding affinityExpand
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