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NKT cells: what's in a name?
Recent years have seen so-called natural killer T (NKT) cells emerge as important regulators of the immune response. The existence of NKT-cell subsets, and other types of T cell that resemble NKTExpand
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Toward an understanding of NKT cell biology: progress and paradoxes.
Natural killer T (NKT) cells constitute a conserved T cell sublineage with unique properties, including reactivity for a synthetic glycolipid presented by CD1d, expression of an invariant T cellExpand
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The unconventional lifestyle of NKT cells
Many characteristics distinguish CD1d-reactive natural killer T (NKT) cells that express the invariant Vα14–Jα18 T-cell receptor (known here as Vα14i T cells) from conventional T cells. Because ofExpand
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Tracking the Response of Natural Killer T Cells to a Glycolipid Antigen Using Cd1d Tetramers
A major group of natural killer (NK) T cells express an invariant Vα14+ T cell receptor (TCR) specific for the lipoglycan α-galactosylceramide (α-GalCer), which is presented by CD1d. These cells mayExpand
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Interleukin 10 acts on regulatory T cells to maintain expression of the transcription factor Foxp3 and suppressive function in mice with colitis
Regulatory T cells (Treg cells) that express the transcription factor Foxp3 suppress the activity of other cells. Here we show that interleukin 10 (IL-10) produced by CD11b+ myeloid cells inExpand
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Essential role of NKT cells producing IL-4 and IL-13 in the development of allergen-induced airway hyperreactivity
Using natural killer T (NKT) cell–deficient mice, we show here that allergen-induced airway hyperreactivity (AHR), a cardinal feature of asthma, does not develop in the absence of Vα14i NKT cells.Expand
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Constitutive Cytokine mRNAs Mark Natural Killer (NK) and NK T Cells Poised for Rapid Effector Function
Natural killer (NK) and NK T cells are tissue lymphocytes that secrete cytokines rapidly upon stimulation. Here, we show that these cells maintain distinct patterns of constitutive cytokine mRNAs.Expand
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Invariant NKT Cells Amplify the Innate Immune Response to Lipopolysaccharide1
NKT cells are thought of as a bridge between innate and adaptive immunity. In this study, we demonstrate that mouse NKT cells are activated in response to Escherichia coli LPS, and produce IFN-γ, butExpand
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Going both ways: immune regulation via CD1d-dependent NKT cells.
NKT cells are a unique T lymphocyte sublineage that has been implicated in the regulation of immune responses associated with a broad range of diseases, including autoimmunity, infectious diseases,Expand
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Recognition of bacterial glycosphingolipids by natural killer T cells
Natural killer T (NKT) cells constitute a highly conserved T lymphocyte subpopulation that has the potential to regulate many types of immune responses through the rapid secretion of cytokines. NKTExpand
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