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Cell biology of the glomerular podocyte.
TLDR
This review integrates recent physiological and molecular understanding of the role of podocytes during the maintenance and failure of the glomerular filtration barrier with hereditary nephrotic syndromes identified over the last 2 years. Expand
A reference panel of 64,976 haplotypes for genotype imputation
TLDR
A reference panel of 64,976 human haplotypes at 39,235,157 SNPs constructed using whole-genome sequence data from 20 studies of predominantly European ancestry leads to accurate genotype imputation at minor allele frequencies as low as 0.1% and a large increase in the number of SNPs tested in association studies. Expand
Netting Neutrophils Induce Endothelial Damage, Infiltrate Tissues, and Expose Immunostimulatory Molecules in Systemic Lupus Erythematosus
TLDR
The results expand the potential pathogenic roles of aberrant lupus neutrophils and suggest that dysregulation of NET formation and its subsequent responses may play a prominent deleterious role. Expand
Hypoxia promotes fibrogenesis in vivo via HIF-1 stimulation of epithelial-to-mesenchymal transition.
TLDR
Clinical and genetic evidence is provided that activation of HIF-1 signaling in renal epithelial cells is associated with the development of chronic renal disease and may promote fibrogenesis by increasing expression of extracellular matrix-modifying factors and lysyl oxidase genes and by facilitating EMT. Expand
Mouse models of diabetic nephropathy.
TLDR
This interim report and an online supplement detail the progress made toward a complete murine model of human diabetic kidney disease and the critical analysis of existing murine models, which substantially enhances the understanding of this disease process. Expand
Induction of B7-1 in podocytes is associated with nephrotic syndrome.
TLDR
Upregulation of B7-1 in podocytes may contribute to the pathogenesis of proteinuria by disrupting the glomerular filter and provides a novel molecular target to tackle proteinuric kidney diseases. Expand
The glomerular slit diaphragm is a modified adherens junction.
TLDR
A P-cadherin-based adherens junction is well-suited to explain the zipper-like structure of the slit diaphragm, and the present study should allow new avenues leading to the identification of additional slit diphragm-associated proteins conferring specificity to this unique cell junction. Expand
Modification of kidney barrier function by the urokinase receptor
TLDR
It is shown that induction of urokinase receptor (uPAR) signaling in podocytes leads to foot process effacement and urinary protein loss via a mechanism that includes lipid-dependent activation of αvβ3 integrin. Expand
Role of mTOR in podocyte function and diabetic nephropathy in humans and mice.
TLDR
It is suggested that mTOR inhibition can protect podocytes and prevent progressive diabetic nephropathy and demonstrate the requirement for tightly balanced mTOR activity in podocyte homeostasis. Expand
Proteolytic processing of dynamin by cytoplasmic cathepsin L is a mechanism for proteinuric kidney disease.
TLDR
Dynamin is identified as a critical regulator of renal permselectivity that is specifically targeted by proteolysis under pathological conditions and restored podocyte function and resolve proteinuria. Expand
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