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Alveolar Recruitment Promotes Homogeneous Surfactant Distribution in a Piglet Model of Lung Injury
TLDR
It is concluded that volume recruitment by means of increased tidal volumes at the time of surfactant administration leads to a superior Surfactant effect owing to more homogeneous surfactants distribution within a collapsed lung.
Chest physiotherapy in mechanically ventilated children: A review
TLDR
CP in mechanically ventilated children may not be considered a standard therapy despite its widespread use, and controlled studies examining the impact of CP on the duration of mechanical ventilatory support, critical illness, and hospital stay are needed.
Improved pulmonary function by acid sphingomyelinase inhibition in a newborn piglet lavage model.
RATIONALE In acute inflammatory lung disease in newborn infants, exogenous surfactant only transiently improves lung function. We hypothesized that the transient nature of this protection is in part
Gender-based differences in children with sepsis and ARDS: The ESPNIC ARDS Database Group
TLDR
Factors others than testosterone are involved in the male preponderance in severe sepsis in prepubertal patients in spite of low levels of male sex hormones at this age.
Diagnosis and management of cerebral salt wasting (CSW) in children: the role of atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP)
TLDR
Natriuresis and polyuria are the main diagnostic criteria for CSW, and the length of the disease is self-limited and generally ceases within 2 weeks, while Na+, K+, and fluid turnover should be monitored carefully.
Selective NF-kappaB inhibition, but not dexamethasone, decreases acute lung injury in a newborn piglet airway inflammation model.
TLDR
IKK-NBD admixture to surfactant in acute neonatal respiratory failure is superior to dexamethasone administration within the first 24h, as evidenced by reduction in PMNL migration into lung tissue due to reduced nuclear NF-kappaB activity.
Treatment of Respiratory Failure with Inhaled Nitric Oxide and High- Frequency Ventilation in an Infant with Respiratory Syncytial Virus Pneumonia and Bronchopulmonary Dysplasia
TLDR
The combined therapy of HFV and iNO is superior to either therapeutic modality alone in the treatment of hypoxemic respiratory failure due to RSV pneumonia and should be considered in pediatric patients.
ALTERED PULMONARY INTERLEUKIN-6 SIGNALING IN PRETERM INFANTS DEVELOPING BRONCHOPULMONARY DYSPLASIA
TLDR
The authors conclude that altered interleukin-6 signaling via the soluble receptors sIL-6R and sgp130 may play an important role in pulmonary inflammation of preterm infants.
Site‐specific and endothelial‐mediated dysfunction of the alveolar‐capillary barrier in response to lipopolysaccharides
TLDR
Factors associated with LPS‐mediated lung injury such as ICAM‐1, VCAM‐ 1, Angiopoietin 2, complement factors and cathepsin S are revealed, emphasizing the role of epithelial–endothelial crosstalk in the ACB in ALI/ARDS.
Comparison of noise levels caused by four different neonatal high-frequency ventilators
TLDR
It is concluded that neonatal high-frequency ventilators do not represent a major contribution to noise levels for newborns in neonatal intensive care units (NICUs).
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