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Structure Property Relationships of Carboxylic Acid Isosteres
This study reports the structure–property relationships (SPR) of 35 phenylpropionic acid derivatives, in which the carboxylic acid moiety is replaced with a series of known isosteres and provides an assessment of the relative impact on the physicochemical properties that these replacements may have compared to the car boxylic Acid analog.
Aerobic copper-catalyzed organic reactions.
- S. Allen, Ryan R. Walvoord, Rosaura Padilla-Salinas, M. Kozlowski
- ChemistryChemical reviews
- 20 June 2013
The chemistry of copper is extremely rich because it can easily access Cu0, CuI, CuII, and CuIII oxidation states allowing it to act through one-electron or two-Electron processes, which feature confer a remarkably broad range of activities allowing copper to catalyze the oxidation and oxidative union of many substrates.
A priori theoretical prediction of selectivity in asymmetric catalysis: design of chiral catalysts by using quantum molecular interaction fields.
C2-Symmetric Copper(II) Complexes as Chiral Lewis Acids. Scope and Mechanism of Catalytic Enantioselective Aldol Additions of Enolsilanes to (Benzyloxy)acetaldehyde
C2-Symmetric bis(oxazolinyl)pyridine (pybox)−Cu(II) complexes have been shown to catalyze enantioselective Mukaiyama aldol reactions between (benzyloxy)acetaldehyde and a variety of silylketene…
Chemoselective Activation of sp3 vs sp2 C–H Bonds with Pd(II)
- John M. Curto, M. Kozlowski
- Chemistry, BiologyJournal of the American Chemical Society
- 25 November 2014
The first selective coupling of a carbon nucleophile with methyl, ethyl, propyl, and butyl arenes in the absence of a directing group is described, and the observed reactivity establishes that typical reaction solvents can readily participate in C–H activation chemistry.
Asymmetric Oxidative Coupling of Phenols and Hydroxycarbazoles
Generation of a more vanadium catalyst by ligand design and by addition of an exogenous Brønsted or Lewis acid was found to be key to coupling the more oxidatively resistant phenols.
Chorismate-Utilizing Enzymes Isochorismate Synthase, Anthranilate Synthase, and P-Aminobenzoate Synthase - Mechanistic Insight Through Inhibitor Design
Asymmetric Total Synthesis of Nigerone and ent‐Nigerone: Enantioselective Oxidative Biaryl Coupling of Highly Hindered Naphthols
An enantioselective synthesis of the chiral bisnaphthopyrone natural product nigerone and its enantiomer, ent-nigerone, has been realized. The use of constrained 2-naphthol substrates was critical to…
Aerobic Copper‐Catalyzed Organic Reactions
Discovery and structure-activity relationships of sulfonamide ETA-selective antagonists.
Structural features which were important to activity included a 1,5-substitution pattern on the naphthalene ring; a sulfonamide NH with a pK value < 7; an amine, preferably with alkyl substituents, at the 5-position; and methyl groups on both the 3- and 4-positions of the isoxazole.