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Shark variable new antigen receptor biologics – a novel technology platform for therapeutic drug development
Introduction: Biologics drugs have succeeded in achieving a commercial dominance in the global market for new therapies and large pharmaceutical companies' interest remains strong through a continuedExpand
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Therapeutic Potential of Shark Anti-ICOSL VNAR Domains is Exemplified in a Murine Model of Autoimmune Non-Infectious Uveitis
Induced costimulatory ligand (ICOSL) plays an important role in the activation of T cells through its interaction with the inducible costimulator, ICOS. Suppression of full T cell activation can beExpand
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Novel, Anti-hTNF-α Variable New Antigen Receptor Formats with Enhanced Neutralizing Potency and Multifunctionality, Generated for Therapeutic Development
The management of chronic inflammatory diseases, such as inflammatory bowel disease, psoriasis, and rheumatoid arthritis has significantly improved over the last decade with the clinical availabilityExpand
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In Vitro Maturation of a Humanized Shark VNAR Domain to Improve Its Biophysical Properties to Facilitate Clinical Development
Molecular engineering to increase the percentage identity to common human immunoglobulin sequences of non-human therapeutic antibodies and scaffolds has become standard practice. This strategy isExpand
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Anti-ICOSL New Antigen Receptor Domains Inhibit T Cell Proliferation and Reduce the Development of Inflammation in the Collagen-Induced Mouse Model of Rheumatoid Arthritis
Lymphocyte costimulation plays a central role in immunology, inflammation, and immunotherapy. The inducible T cell costimulator (ICOS) is expressed on T cells following peptide: MHC engagement withExpand
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Next-generation flexible formats of VNAR domains expand the drug platform's utility and developability.
TLDR
Smaller, less complex binders, with increased domain valency, multi-specific/paratopic targeting, tuneable serum half-life and low inherent immunogenicity are a few of the characteristics being explored by the next generation of biologic molecules. Expand
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INFLUENCE OF HEAT TREATMENT ON THE MICROSTRUCTURE AND PHASE COMPOSITIONS OF DETONATION NANOSTRUCTURED ALUMINA COATINGS
In this study the effect of heat treatment on air on the microstructure and phase compositions of nanostructured Al2O3 coatings, obtained by multi-chamber gas-dynamic accelerator, was investigatedExpand
Effect of Heat Treatment of the Alumina Powder on the Microstructure and Properties of Coatings
The alumina powder was treated at a high temperature (1000°C). Dense (porosity of less than 2%), solid (1280 ± 30 HV0.3) and wear-resistant coatings based on heat-treated alumina powder were obtainedExpand