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Erythropoietin retards DNA breakdown and prevents programmed death in erythroid progenitor cells.
The mechanism by which erythropoietin controls mammalian erythrocyte production is unknown. Labeling experiments in vitro with [3H]thymidine demonstrated DNA cleavage in erythroid progenitor cells… Expand
New insights into erythropoiesis: the roles of folate, vitamin B12, and iron.
Erythropoiesis is the process in which new erythrocytes are produced. These new erythrocytes replace the oldest erythrocytes (normally about one percent) that are phagocytosed and destroyed each day.… Expand
Fus deficiency in mice results in defective B-lymphocyte development and activation, high levels of chromosomal instability and perinatal death
The gene FUS (also known as TLS (for translocated in liposarcoma) and hnRNP P2) is translocated with the gene encoding the transcription factor ERG-1 in human myeloid leukaemias. Although the… Expand
Plasma S-adenosylhomocysteine is a more sensitive indicator of cardiovascular disease than plasma homocysteine.
- D. Kerins, M. Koury, A. Capdevila, S. Rana, C. Wagner
- The American journal of clinical nutrition
- 1 December 2001
BACKGROUND Although plasma total homocysteine has been identified as an independent risk factor for vascular disease in a multitude of studies, there is a considerable overlap in values between… Expand
Anaemia in kidney disease: harnessing hypoxia responses for therapy
Improved understanding of the oxygen-dependent regulation of erythropoiesis has provided new insights into the pathogenesis of anaemia associated with renal failure and has led to the development of… Expand
Cytoskeletal distribution and function during the maturation and enucleation of mammalian erythroblasts
We have used murine splenic erythrolasts infected with the anemia- inducing strain of Friend virus (FVA cells), as an in vitro model to study cytoskeletal elements during erythroid maturation and… Expand
The molecular mechanism of erythropoietin action.
Erythropoietin (EPO) is the glycoprotein hormone which controls the production of erythrocytes in mammals. Erythrocytes contain hemoglobin which delivers oxygen from the lungs to other tissues… Expand
New insights into erythropoiesis
Commitment of hematopoietic cells to the erythroid lineage involves the actions of several transcription factors, including TAL1, LMO2, and GATA-2. The differentiation of committed erythroid… Expand
Ferric citrate controls phosphorus and delivers iron in patients on dialysis.
- J. Lewis, M. Sika, +16 authors J. Dwyer
- Chemistry, Medicine
- Journal of the American Society of Nephrology…
- 1 February 2015
Patients on dialysis require phosphorus binders to prevent hyperphosphatemia and are iron deficient. We studied ferric citrate as a phosphorus binder and iron source. In this sequential, randomized… Expand