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The mitochondrial genome of the Mediterranean fruit fly, Ceratitis capitata
TLDR
The complete sequence of the mitochondrial genome of Ceratitis capitata has been determined and it becomes apparent that interstrain polymorphisms are not rare. Expand
Tissue- and time-dependent transcription in Ixodes ricinus salivary glands and midguts when blood feeding on the vertebrate host
TLDR
massive de novo sequencing is used to characterize the transcriptional dynamics of the salivary and midgut tissues of nymphal and adult I. ricinus at various time points after attachment on the vertebrate host, and hypothesize that gene expression switching may be under epigenetic control. Expand
Selective Cysteine Protease Inhibition Contributes to Blood-feeding Success of the Tick Ixodes scapularis*
TLDR
It is shown that host immunomodulation is implicated in the deleterious phenotype of silenced ticks making I. scapularis cystatins attractive targets for development of antitick vaccines. Expand
Crystal structure and functional characterization of an immunomodulatory salivary cystatin from the soft tick Ornithodoros moubata.
TLDR
It is concluded that OmC2 is a promising target for the development of a novel anti-tick vaccine to control O. moubata populations and combat the spread of associated diseases. Expand
Antiinflammatory and Immunosuppressive Activity of Sialostatin L, a Salivary Cystatin from the Tick Ixodes scapularis*
TLDR
Beyond unraveling another component accounting for the properties of tick saliva, contributing to feeding success and pathogen transmission, this work describes a novel tool for studying the role of papain-like proteases in diverse biologic phenomena and a protein with numerous potential pharmaceutical applications. Expand
The Immunomodulatory Action of Sialostatin L on Dendritic Cells Reveals Its Potential to Interfere with Autoimmunity1
TLDR
SialoL administration during the immunization phase of experimental autoimmune encephalomyelitis in mice significantly prevented disease symptoms, which was associated with impaired IFN-γ and IL-17 production and specific T cell proliferation. Expand
De novo Ixodes ricinus salivary gland transcriptome analysis using two next‐generation sequencing methodologies
TLDR
Detailed phylogenetic reconstructions of two relatively abundant SG‐secreted protein families demonstrated how this study improves the understanding of the molecular evolution of hematophagy in arthropods. Expand
Cutting Edge: Immunity against a “Silent” Salivary Antigen of the Lyme Vector Ixodes scapularis Impairs Its Ability to Feed1
TLDR
It is demonstrated an essential sialostatin L2 role upon nymphal infestation that can be blocked by vertebrate immunity and proposed the discovery of similarly “silent” Ags toward the development of a multicomponent vaccine that will protect against tick bites and the pathogens they transmit. Expand
The crystal structures of two salivary cystatins from the tick Ixodes scapularis and the effect of these inhibitors on the establishment of Borrelia burgdorferi infection in a murine model
TLDR
The crystal structures of both sialostatin L and L2 are determined, revealing the structure of two tick salivary components that facilitate vector blood feeding and that one of them also supports pathogen transmission to the vertebrate host. Expand
sRNAbench: profiling of small RNAs and its sequence variants in single or multi-species high-throughput experiments
TLDR
In order to facilitate the analysis of experimental setups that include genetic material from several species, the sRNAbench program is developed and includes new functionalities such as full isomiR support including statistical test on differential frequency, improved prediction of novel microRNAs, extended summary files and data visualization support. Expand
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