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Expression of Vascular Endothelial Growth Factor in Ovarian Cancer Inhibits Tumor Immunity through the Accumulation of Myeloid-Derived Suppressor Cells
VEGF expression in ovarian cancer induced MDSCs, inhibited local immunity, and contributed to poor prognosis, according to Clin Cancer Res; 23(2); 587–99.
Recent Concepts of Ovarian Carcinogenesis: Type I and Type II
Type I ovarian tumors, where precursor lesions in the ovary have clearly been described, include endometrioid, clear cell, mucinous, low grade serous, and transitional cell carcinomas, while type II
Advanced papillary serous carcinoma of the uterine cervix: a case with a remarkable response to paclitaxel and carboplatin combination chemotherapy
The main tumor of the uterine cervix showed a complete response by magnetic resonance imaging (MRI), and on rebiopsy, more than 95% of the tumor cells in the cervix had microscopically disapperared.
Pathways of Metastases from Primary Organs to the Ovaries
The patients with metastatic ovarian tumors originating from distant organs who were treated at the same time as the original cancers had a significantly poorer prognosis than the patients with ovarian tumors treated later and hypothesized that the rate of intravascular metastasis from the colorectum to the ovary was relatively higher than from the stomach to the Ovary.
Expression of metastasis-related nm23-H1 and nm23-H2 genes in ovarian carcinomas: correlation with clinicopathology, EGFR, c-erbB-2, and c-erbB-3 genes, and sex steroid receptor expression.
To verity the role of metastasis-related nm23 genes in carcinogenesis and progression of ovarian carcinoma, we analyzed the mRNA levels of the nm23 genes of both isoforms, -H1 and -H2, together with
Altered expression of nm23‐H1 and c‐erbB‐2 proteins have prognostic significance in adenocarcinoma but not in squamous cell carcinoma of the uterine cervix
Background. The reduced expression of nm23‐Hl protein and/or overexpression of c‐erbB‐2 protein reportedly is associated with a high incidence of lymphatic metastasis or poor prognosis of the patient
Subtypes of Ovarian Cancer and Ovarian Cancer Screening
Current issues, the efficacy and problems associated with ovarian cancer screening, and the characteristics of ovarian cancer subtypes are discussed, and biomarkers for the early detection of Type II carcinomas such as STICs need to be developed.
Immunohistochemical localization of heat shock proteins HSP70 and HSP90 in the human endometrium: correlation with sex steroid receptors and Ki-67 antigen expression.
The findings suggest that HSP70 expression is related to either hormonal regulation of cell proliferation and/or down-regulation of sex steroid receptors.
Primary malignant tumor of the fallopian tube: appearance at CT and MR imaging.
The lesion appeared relatively small, solid, and lobulated when not associated with hydrosalpinx at CT, and had an attenuation equal to that of other nonspecific soft-tissue masses and enhanced less than myometrium at CT.
Exome Sequencing Landscape Analysis in Ovarian Clear Cell Carcinoma Shed Light on Key Chromosomal Regions and Mutation Gene Networks.
Previous studies have reported genome-wide mutation profile analyses in ovarian clear cell carcinomas (OCCCs). This study aims to identify specific novel molecular alterations by combined analyses of