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Phosphorylation of the eIF4E‐binding protein PHAS‐I after exposure of PC12 cells to EGF and NGF
PHAS‐I or the eIF4E‐binding protein 1 regulates the cap‐binding activity of eIF4E by sequestering eIF4E. Binding of eIF4E to PHAS‐I is regulated by phosphorylation of PHAS‐I. PC12 cells were used toExpand
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Hypoplastic acute leukemia: description of eight cases and search for hematopoietic inhibiting activity
SummaryHypoplastic acute leukemia (HAL) is characterized by pancytopenia and by hypocellularity of the bone marrow. The marrow contains equal to or more than 30% myeloblasts. Absence of tissueExpand
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The nature of the adherent hemopoietic cells in human long-term bone marrow cultures (HLTBMCs): presence of lymphocytes and plasma cells next to the myelomonocytic population.
An immunological analysis of the nonmacrophage hemopoietic cells in the adherent layer of human long-term bone marrow cultures was performed in situ. It revealed not only the expected granulocyticExpand
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A quantitative and dynamic study of endothelial cells and megakaryocytes in human long-term bone marrow cultures.
The quantitative evolution of endothelial cells (ECs) in Dexter-type human long-term bone marrow cultures (HLTBMCs) was investigated. Using monoclonal antibodies directed against von WillebrandExpand
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Karyotypic evidence for the leukemic involvement of the erythroblasts in erythroleukemia.
With the use of a monoclonal anti-glycophorin A antibody and flow cytometric cell sorting, an erythroleukemic bone marrow sample was separated in highly purified erythroblast and myeloblastExpand
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Cimetidine induced pancytopenia
SummaryWe describe a 26 year-old male with a pancytopenia possibly due to cimetidine. Using progenitor cell culture techniques we investigated the mechanism of this bone marrow toxicity. Our resultsExpand
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IN VITRO PRIMING OF HUMAN BONE MARROW WITH RECOMBINANT GM‐CSF
Auk K.A.,Antin, J.H., Ginsburg, D.. Orkin, S.H., Rappeport, J.M., Keohan, M.L., Martin, P. & Smith, B.R. (1985) Phenotype of recovering lymphoid cell populations after marrow transplantation. JournalExpand
Comparison of human long-term bone marrow cultures (HLTBMCs) established from fresh and post-cryopreservation bone marrow samples from living and cadaver donors.
Human long-term bone marrow cultures (HLTBMCs) were established from thawed post-cryopreservation, as well as from cadaver donor bone marrow (BM) samples. The longevity was similar in the differentExpand