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Growth Factor Regulation of Autophagy and Cell Survival in the Absence of Apoptosis
In animals, cells are dependent on extracellular signals to prevent apoptosis. However, using growth factor-dependent cells from Bax/Bak-deficient mice, we demonstrate that apoptosis is not essentialExpand
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Breast cancer-secreted miR-122 reprograms glucose metabolism in pre-metastatic niche to promote metastasis
Reprogrammed glucose metabolism as a result of increased glycolysis and glucose uptake is a hallmark of cancer. Here we show that cancer cells can suppress glucose uptake by non-tumour cells in theExpand
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Alpha4 is an essential regulator of PP2A phosphatase activity.
The activity and specificity of serine/threonine phosphatases are governed largely by their associated proteins. alpha4 is an evolutionarily conserved noncatalytic subunit for PP2A-like phosphatases.Expand
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The PP2A-associated protein alpha4 is an essential inhibitor of apoptosis.
Despite evidence that protein kinases are regulators of apoptosis, a specific role for phosphatases in regulating cell survival has not been established. Here we show that alpha4, a noncatalyticExpand
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Regional glutamine deficiency in tumours promotes dedifferentiation through inhibition of histone demethylation
Poorly organized tumour vasculature often results in areas of limited nutrient supply and hypoxia. Despite our understanding of solid tumour responses to hypoxia, how nutrient deprivation regionallyExpand
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The B55α subunit of PP2A drives a p53-dependent metabolic adaptation to glutamine deprivation.
Glutamine is an essential nutrient for cancer cell survival and proliferation, yet the signaling pathways that sense glutamine levels remain uncharacterized. Here, we report that the proteinExpand
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Structural basis of protein phosphatase 2A stable latency
The catalytic subunit of protein phosphatase 2A (PP2Ac) is stabilized in a latent form by α4, a regulatory protein essential for cell survival and biogenesis of all PP2A complexes. Here we report theExpand
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The PP2A-Associated Protein α4 Is an Essential Inhibitor of Apoptosis
Despite evidence that protein kinases are regulators of apoptosis, a specific role for phosphatases in regulating cell survival has not been established. Here we show that α4, a noncatalytic subunitExpand
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Regulation of Glycogen Synthase in Rat Hepatocytes
We examined the signaling pathways regulating glycogen synthase (GS) in primary cultures of rat hepatocytes. The activation of GS by insulin and glucose was completely reversed by theExpand
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The PP2A-associated Protein α4 Plays a Critical Role in the Regulation of Cell Spreading and Migration*
Compared with kinases, the role of protein phosphatases in regulating biological functions is less well understood. Here we show that α4, a non-catalytic subunit of the protein phosphatase 2A, playsExpand
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