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Role of active oxygen, lipid peroxidation, and antioxidants in the pathogenesis of gastric mucosal injury induced by indomethacin in rats.
TLDR
It is suggested that active oxygen species and lipid peroxidation play an important part in the pathogenesis of gastric mucosal injury induced by indomethacin, and that the decreased glutathione peroxidase activity aggravated the injury due to accelerated accumulation of hydrogen peroxide and lipidperoxides in the gastricucosal cell. Expand
Expression of cyclooxygenase-1 and -2 in human colorectal cancer.
TLDR
The data suggest that the enhanced expression of the COX-2 gene in Colon cancer tissues may contribute to the enhanced synthesis of prostaglandin E2 by the colon cancer tissues. Expand
Role of oxygen radical and lipid peroxidation in indomethacin-induced gastric mucosal injury.
TLDR
Both allopurinol, an inhibitor of xanthine oxidase, and neutrophil depletion by intraperitoneal injection of antineutrophil antibody significantly attenuates indomethacin-induced gastric injury. Expand
A new mechanism for anti‐inflammatory actions of proton pump inhibitors – inhibitory effects on neutrophil–endothelial cell interactions
Background: Neutrophil–endothelial cell interactions mediated by adhesion molecules may be involved in gastric mucosal inflammation associated with Helicobacter pylori or nonsteroidalExpand
15-deoxy-delta(12,14)-PGJ(2) induces synoviocyte apoptosis and suppresses adjuvant-induced arthritis in rats.
TLDR
It is demonstrated that synovial tissue localized expression of PPAR-gamma in patients with rheumatoid arthritis (RA) and its ligands, especially 15d-PGJ(2), may be useful in the treatment of RA, suggesting that PPAR -gamma may be an important immunoinflammatory mediator. Expand
A novel cancer therapy based on oxygen radicals.
TLDR
It is suggested that oxygen radicals produced by hypoxanthine and xanthine oxidase reaction produce an anticancer effect and that the VX2 carcinoma used in this study was more sensitive to oxygen radicals than normal muscle tissue. Expand
Role of neutrophil-mediated inflammation in aspirin-induced gastric mucosal injury
TLDR
Results suggest that neutrophil-endothelial adhesive interactions, which occur via CD11a/CD18-and CD11b/ CD18-dependent interactions with intercellular adhesion molecule-1, and oxygen-derived free radicals produced by neutrophils are implicated in the production of aspirin-induced gastric mucosal injury. Expand
Urocortin expression in synovium of patients with rheumatoid arthritis and osteoarthritis: relation to inflammatory activity.
TLDR
Findings suggest that, like CRH, urocortin is present in peripheral inflammatory sites, such as rheumatoid synovium, and acts as an immune-inflammatory mediator. Expand
15-deoxy-Δ12,14-PGJ2 induces synoviocyte apoptosis and suppresses adjuvant-induced arthritis in rats
TLDR
It is demonstrated that synovial tissue localized expression of PPAR-γ in patients with rheumatoid arthritis (RA) and its ligands, especially 15d-PGJ2, may be useful in the treatment of RA, to suggest that PPar-γ may be an important immunoinflammatory mediator. Expand
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