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The neurobiology of psychedelic drugs: implications for the treatment of mood disorders
TLDR
Recent behavioural and neuroimaging data show that psychedelics modulate neural circuits that have been implicated in mood and affective disorders, and can reduce the clinical symptoms of these disorders.
Acute, subacute and long-term subjective effects of psilocybin in healthy humans: a pooled analysis of experimental studies
TLDR
The results suggest that the administration of moderate doses of psilocybin to healthy, high-functioning and well-prepared subjects in the context of a carefully monitored research environment is associated with an acceptable level of risk.
Activation of Serotonin 2A Receptors Underlies the Psilocybin-Induced Effects on α Oscillations, N170 Visual-Evoked Potentials, and Visual Hallucinations
TLDR
It is found that psilocybin strongly decreased prestimulus parieto-occipital α power values, thus precluding a subsequent stimulus-induced α power decrease, and the observed reduction of N170 visual-evoked potentials may be a key mechanism underlying 5-HT2A receptor-mediated visual hallucinations.
Prediction of Psilocybin Response in Healthy Volunteers
TLDR
Having a high score in the personality trait of Absorption, being in an emotionally excitable and active state immediately before drug intake, and having experienced few psychological problems in past weeks were most strongly associated with pleasant and mystical-type experiences to psilocybin.
Modeling ketamine effects on synaptic plasticity during the mismatch negativity.
TLDR
A concrete mechanism for ketamine effects on MMN that correlates with drug-induced psychopathology is suggested, and the potential of modeling for inferring on synaptic physiology, and its pharmacological modulation, from electroencephalography data is demonstrated.
Psilocybin-induced spiritual experiences and insightfulness are associated with synchronization of neuronal oscillations
TLDR
These results provide systematic evidence for the direct association of a specific spatiotemporal neuronal mechanism with spiritual experiences and enhanced insight into life and existence and may constitute a pathway for modulating mental health.
Effect of Psilocybin on Empathy and Moral Decision-Making
TLDR
These findings provide first evidence that psilocybin has distinct effects on social cognition by enhancing emotional empathy but not moral behavior, and suggest that targeting serotonin 2A/1A receptors has implications for potential treatment of dysfunctional social cognition.
Psilocybin-Induced Deficits in Automatic and Controlled Inhibition are Attenuated by Ketanserin in Healthy Human Volunteers
TLDR
It is suggested that the disrupting effects of psilocybin on automatic and controlled inhibition processes are attributable to 5-HT2AR stimulation, and ketanserin alone had no significant effects.
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