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A Population of Multipotent CD34-Positive Adipose Stromal Cells Share Pericyte and Mesenchymal Surface Markers, Reside in a Periendothelial Location, and Stabilize Endothelial Networks
It has been shown that stromal–vascular fraction isolated from adipose tissues contains an abundance of CD34+ cells. Histological analysis of adipose tissue revealed that CD34+ cells are widelyExpand
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Reversal of obesity by targeted ablation of adipose tissue
Obesity is an increasingly prevalent human condition in developed societies. Despite major progress in the understanding of the molecular mechanisms leading to obesity, no safe and effectiveExpand
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Steps toward mapping the human vasculature by phage display
The molecular diversity of receptors in human blood vessels remains largely unexplored. We developed a selection method in which peptides that home to specific vascular beds are identified afterExpand
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  • Open Access
PRUNE2 is a human prostate cancer suppressor regulated by the intronic long noncoding RNA PCA3
Significance Prostate cancer has an unpredictable natural history: While most tumors are clinically indolent, some patients display lethal phenotypes. Serum prostate-specific antigen is the mostExpand
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  • Open Access
Omental Adipose Tissue–Derived Stromal Cells Promote Vascularization and Growth of Endometrial Tumors
Purpose: Adipose tissue contains a population of tumor-tropic mesenchymal progenitors, termed adipose stromal cells (ASC), which engraft in neighboring tumors to form supportive tumor stroma. WeExpand
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  • Open Access
A framework for advancing our understanding of cancer-associated fibroblasts
Cancer-associated fibroblasts (CAFs) are a key component of the tumour microenvironment with diverse functions, including matrix deposition and remodelling, extensive reciprocal signallingExpand
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Display technologies: Application for the discovery of drug and gene delivery agents☆
Abstract Recognition of molecular diversity of cell surface proteomes in disease is essential for the development of targeted therapies. Progress in targeted therapeutics requires establishingExpand
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White adipose tissue cells are recruited by experimental tumors and promote cancer progression in mouse models.
The connection between obesity and accelerated cancer progression has been established, but the mediating mechanisms are not well understood. We have shown that stromal cells from white adiposeExpand
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  • Open Access
An isoform of decorin is a resistin receptor on the surface of adipose progenitor cells.
Adipose stromal cells (ASCs) serve as mesenchymal progenitors in white adipose tissue (WAT). Intercellular interactions involving ASCs have remained obscure. By merging phage display technology withExpand
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Influence of BMI on Level of Circulating Progenitor Cells
Obesity complicates a number of diseases through mechanisms that are poorly defined. Mobilization and recruitment of progenitor cells to pathological sites is an important factor in diseaseExpand
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