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Heart rate variability and inflammatory response in rats with lipopolysaccharide-induced endotoxemia.
Reduced HRV in HF band may indicate a decreased parasympathetic activity in LPS-induced endotoxemia as basic characteristics of altered cardiac control during response to endot oxemia. Expand
Pulmonary surfactant and bacterial lipopolysaccharide: the interaction and its functional consequences.
It is of clinical importance that endotoxin-induced lung injury can be favorably influenced by intratracheal instillation of exogenous surfactants, and it is believed that the surfactant preparations have anti-inflammatory properties through regulating cytokine production by inflammatory cells. Expand
Vagal-immune interactions involved in cholinergic anti-inflammatory pathway.
This review summarizes and critically assesses the current knowledge defining cholinergic anti-inflammatory pathway with main focus on studies employing an experimental approach and emphasizes the potential of modulation of vagally-mediated anti- inflammation pathway in the treatment strategies. Expand
Reduction of lung inflammation, oxidative stress and apoptosis by the PDE4 inhibitor roflumilast in experimental model of acute lung injury.
Treatment with roflumilast reduced leak of cells, particularly of neutrophils, into the lung, decreased concentrations of cytokines and oxidative products in the lung and plasma, and reduced lung cell apoptosis and edema formation. Expand
Effects of phosphodiesterase 5 inhibitor sildenafil on the respiratory parameters, inflammation and apoptosis in a saline lavage-induced model of acute lung injury.
A future potential of PDE5 inhibitors also for the therapy of ALI is indicated, with positive effects of sildenafil treatment result from influencing proliferation of regulatory T cells and production of proinflammatory cytokines and autoantibodies as well as from modulation of platelet activation, angiogenesis, and pulmonary vasoreactivity. Expand
Comorbidity has no impact on eosinophil inflammation in the upper airways or on severity of the sinonasal disease in patients with nasal polyps
The study was designed to determine whether there is an association between the comorbidity as atopy, bronchial asthma, aspirin intolerance and eosinophil infiltration of the upper airways, severityExpand
Effects of roflumilast, a phosphodiesterase-4 inhibitor, on the lung functions in a saline lavage-induced model of acute lung injury.
Results indicate a future potential of PDE4 inhibitors also in the therapy of ALI and reduce leak of cells into the lung, decreased lung edema formation, and improved respiratory parameters. Expand
N-acetylcysteine advancement of surfactant therapy in experimental meconium aspiration syndrome: possible mechanisms.
NAC suppressed IL-8 and IL-beta formation and thus seems to be favorable agent for improving surfactant therapy in MAS, and was the only treatment which prevented neutrophil migration into the lungs, oxidative damage and lung edema. Expand
Intravenous dexamethasone attenuated inflammation and influenced apoptosis of lung cells in an experimental model of acute lung injury.
Results indicate potential of this therapy in ALI and show trend to improve lung functions and histopathological changes, reduced leak of neutrophils into the lung, decreased concentrations of pro-inflammatory IL-1beta and marker of lung injury esRAGE, but increased immunoreactivity of caspase-3 in the lung. Expand
Selective inhibition of NF-kappaB and surfactant therapy in experimental meconium-induced lung injury.
It seems that inhibition of inflammation may be strong supporting factor in surfactant treatment of MAS, as it improved oxygenation, reduced neutrophil count in BALF and levels of IL-1beta, IL-6, p38 MAPK and caspase 3 in comparison with surfactan-only therapy. Expand