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Epidemiology and outcomes of health-care-associated pneumonia: results from a large US database of culture-positive pneumonia.
TLDR
Compared with CAP, non-CAP was associated with more severe disease, higher mortality rate, greater LOS, and increased cost, and the present analysis justified HCAP as a new category of pneumonia. Expand
Effect of a nursing-implemented sedation protocol on the duration of mechanical ventilation.
TLDR
The use of protocol-directed sedation can reduce the duration of mechanical ventilation, the intensive care unit and hospital lengths of stay, and the need for tracheostomy among critically ill patients with acute respiratory failure. Expand
The use of continuous i.v. sedation is associated with prolongation of mechanical ventilation.
TLDR
This study suggests that strategies targeted at reducing the use of continuous i.v. sedation could shorten the duration of mechanical ventilation for some patients. Expand
The influence of inadequate antimicrobial treatment of bloodstream infections on patient outcomes in the ICU setting.
TLDR
The data suggest that clinical efforts should be aimed at reducing the administration of inadequate antimicrobial treatment to hospitalized patients with bloodstream infections, especially individuals infected with antibiotic-resistant bacteria and Candida species. Expand
Inadequate antimicrobial treatment of infections: a risk factor for hospital mortality among critically ill patients.
TLDR
Inadequate treatment of infections among patients requiring ICU admission appears to be an important determinant of hospital mortality, and clinical efforts aimed at reducing the occurrence of inadequate antimicrobial treatment could improve the outcomes of critically ill patients. Expand
Epidemiology and outcomes of ventilator-associated pneumonia in a large US database.
TLDR
It is demonstrated that VAP is a common nosocomial infection that is associated with poor clinical and economic outcomes and strategies to prevent the occurrence of VAP may not reduce mortality, but they may yield other important benefits to patients, their families, and hospital systems. Expand
Ventilator-associated pneumonia. A multivariate analysis.
TLDR
Potential interventions that might affect the incidence of VAP or outcome associated with VAP are suggested and indicate that different ICU populations may have different incidences of V AP. Expand
Linezolid in methicillin-resistant Staphylococcus aureus nosocomial pneumonia: a randomized, controlled study.
TLDR
Clinical response at EOS in the PP population was significantly higher with linezolid than with vancomycin, although 60-day mortality was similar, and survival and safety were also evaluated. Expand
The Epidemiology, Pathogenesis and Treatment of Pseudomonas aeruginosa Infections
TLDR
The effective treatment of infections caused by P. aeruginosa includes prevention when possible, source control measures as necessary and prompt administration of appropriate antibacterial agents, especially when antibacterial susceptibilities are known. Expand
Delaying the Empiric Treatment of Candida Bloodstream Infection until Positive Blood Culture Results Are Obtained: a Potential Risk Factor for Hospital Mortality
TLDR
Delayed treatment of Candida bloodstream infections could be minimized by the development of more rapid diagnostic techniques for the identification of CandIDA bloodstream infections and increased use of empiric antifungal treatment in selected patients at high risk for fungal bloodstream infection could also reduce delays in treatment. Expand
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