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Ghrelin and des-acyl ghrelin: two major forms of rat ghrelin peptide in gastrointestinal tissue.
Ghrelin, a novel peptide purified from stomach, is the endogenous ligand for the growth hormone secretagogue receptor and has potent growth hormone-releasing activity. The Ser3 residue of ghrelin isExpand
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Cloning and characterization of cDNA encoding a precursor for human adrenomedullin.
Adrenomedullin is a novel hypotensive peptide recently isolated from human pheochromocytoma. Since a high concentration of immunoreactive adrenomedullin was found in pheochromocytoma tissue, the cDNAExpand
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Purification and Characterization of Rat des-Gln14-Ghrelin, a Second Endogenous Ligand for the Growth Hormone Secretagogue Receptor*
Ghrelin, a peptide purified from the stomach, is an endogenous ligand for the growth hormone secretagogue receptor (GHS-R) and potently stimulates growth hormone release from the pituitary. GhrelinExpand
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Structure-activity relationship of ghrelin: pharmacological study of ghrelin peptides.
Ghrelin, a novel peptide purified from the stomach, is the endogenous ligand of the growth hormone secretagogue receptor. The Ser(3) residue of ghrelin is modified with a lipid n-octanoic acid, aExpand
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Enzymic and structural characterization of nepenthesin, a unique member of a novel subfamily of aspartic proteinases.
Carnivorous plants are known to secrete acid proteinases to digest prey, mainly insects, for nitrogen uptake. In the present study, we have purified, for the first time, to homogeneity two acidExpand
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Complete amino acid sequence of porcine adrenomedullin and cloning of cDNA encoding its precursor
Porcine adrenomedullin was isolated from adrenal medulla extract and its amino acid sequence was determined. The peptide is identical to human adrenomedullin with a single replacement of Gly for AsnExpand
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Cloning and sequence analysis of cDNA encoding a precursor for human brain natriuretic peptide.
Brain natriuretic peptide (BNP) is a novel diuretic-natriuretic and vasorelaxant peptide originally isolated from porcine brain. In contrast to mammalian atrial natriuretic peptide (ANP),Expand
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Bullfrog Ghrelin Is Modified by n-Octanoic Acid at Its Third Threonine Residue*
We have identified the amphibian ghrelin from the stomach of the bullfrog. We also examined growth hormone (GH)-releasing activity of this novel peptide in both the rat and bullfrog. The three formsExpand
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Post-translational processing of the phosphatidylserine decarboxylase gene product in Chinese hamster ovary cells.
We have isolated a full-length cDNA clone of the Chinese hamster ovary (CHO) pssC gene, which encodes mitochondrial phosphatidylserine decarboxylase. The cDNA clone is capable of increasingExpand
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Cloning and sequence analysis of a cDNA encoding a precursor for rat C‐type natriuretic peptide (CNP)
Recent identification of a C‐type natriuretic peptide (CNP) in porcine brain strongly suggested that a third member of the natriuretic peptide family still remains to be identified in other speciesExpand
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