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Tetrahydroisoquinoline and 1-methyl-tetrahydroisoquinoline as novel endogenous amines in rat brain.
TLDR
This is the first report to identify 1,2,3,4-tetrahydroisoquinoline and 1-methyl-1, 2, 3, 4-Tetrahyrosine as endogenous amines from non-treated rat brain, which might be endogenous substances inducing parkinsonism. Expand
Metabolic fate of the new angiotensin-converting enzyme inhibitor imidapril in animals. 2nd communication: tissue distribution and whole-body autoradiography of imidapril in rats.
TLDR
There was no specific binding of drug-related compounds to melanin-containing tissues such as the hair follicles and the uveal tract of the eye in the pigmented rats. Expand
Metabolic fate of the new angiotensin-converting enzyme inhibitor imidapril in animals. 4th communication: placental transfer and secretion into milk in rats.
TLDR
The present autoradiographic findings confirmed the above results of tissue distribution studies and indicates that the substance-associated radioactivity penetrates the placental barrier to a low extent. Expand
Metabolic fate of the new angiotensin-converting enzyme inhibitor imidapril in animals. 6th communication: interspecies comparison of pharmacokinetics and excretion of imidapril metabolites in rats,
TLDR
Irrespective of the route of administration, unchanged imidapril disappeared more rapidly from the plasma in rats than in dogs and the half-lives of plasma M1 levels were similar to those after oral dosing. Expand
Metabolic fate of the new angiotensin-converting enzyme inhibitor imidapril in animals. 1st communication: absorption, pharmacokinetics and excretion in rats and dogs.
TLDR
In situ absorption study showed that [N-methyl-14C]-imidapril was absorbed from nearly the entire rat small intestine, especially from the jejunum, but hardly absorbed from the stomach, while disappearance of unchanged drug from the plasma was much faster in rats than in dogs. Expand
Structure-activity relationships of phenylethylamine analogs in their serotonergic depressant effects on the spinal monosynaptic reflex in rats.
TLDR
The results suggest that PEA-related compounds cause MSR depression by direct and indirect 5- HT agonistic mechanisms, and support the proposal that the PEA moiety which exists in R(+)-2-aminotetralin is important for the direct 5-HT agonistic activity of some hallucinogens. Expand
Metabolic fate of the new angiotensin-converting enzyme inhibitor imidapril in animals. 3rd communication: tissue accumulation after consecutive oral administration of [N-methyl-14C]-imidapril in
TLDR
Examination of the time course of plasma radioactivity after the single and multiple (7 and 14 times) oral administration revealed that the Cmax and AUCO-24 h values slightly, but significantly, increased according to repeated dosing and the beta-phase of the t1/2 of disappearance became longer after consecutive dosing. Expand
Metabolic Fate of the New β-Adrenoceptor Antagonist, Bisoprolol, in Animals (2) : Tissue Accumulation after Consecutive Oral Administration of 14C-Bisoprolol in Rats
Accumulation characteristics of bisoprolol were studied in male rats after the consecutive oral administration (1 mg/kg/day) of 14C-bisoprolol for 14 days.1. After single oral administration ofExpand
Metabolic fate of the new anti-ulcer drug enprostil in animals. 3rd communication: tissue accumulation after consecutive oral administration of [3H]-enprostil in rats.
TLDR
The retention of non-volatile radioactivity was observed in most tissues and the ratios of volatile tritium to total radioactivity in plasma increased with repeated administration of [3H]-enprostil and the levels of volatiletritium were almost equilibrated within 7 days of drug administration. Expand
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